Articles | Volume 7, issue 1
https://doi.org/10.5194/jbji-7-11-2022
https://doi.org/10.5194/jbji-7-11-2022
Original full-length article
 | 
20 Jan 2022
Original full-length article |  | 20 Jan 2022

Local antibiotic treatment with calcium sulfate as carrier material improves the outcome of debridement, antibiotics, and implant retention procedures for periprosthetic joint infections after hip arthroplasty – a retrospective study

Katharina Reinisch, Michel Schläppi, Christoph Meier, and Peter Wahl

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Cited articles

Aboltins, C., Dowsey, M. M., Peel, T., Lim, W. K., Parikh, S., Stanley, P., and Choong, P. F.: Early prosthetic hip joint infection treated with debridement, prosthesis retention and biofilm-active antibiotics: functional outcomes, quality of life and complications, Intern. Med. J., 43, 810–815, 2013. 
Abosala, A. and Ali, M.: The Use of Calcium Sulphate beads in Periprosthetic Joint Infection, a systematic review, J. Bone Joint Infect., 5, 43–49, https://doi.org/10.7150/jbji.41743, 2020. 
Achermann, Y., Eigenmann, K., Ledergerber, B., Derksen, L., Rafeiner, P., Clauss, M., Nuesch, R., Zellweger, C., Vogt, M., and Zimmerli, W.: Factors associated with rifampin resistance in staphylococcal periprosthetic joint infections (PJI): a matched case-control study, Infection, 41, 431–437, 2013. 
Anagnostakos, K., Wilmes, P., Schmitt, E., and Kelm, J.: Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo, Acta Orthop., 80, 193–197, 2009. 
Baeza, J., Cury, M. B., Fleischman, A., Ferrando, A., Fuertes, M., Goswami, K., Lidgren, L., Linke, P., Manrique, J., Makar, G., McLaren, A., Moriarty, T. F., Ren, Q., Vince, K., Wahl, P., Webb, J., Winkler, H., Witso, E., and Young, S.: General Assembly, Prevention, Local Antimicrobials: Proceedings of International Consensus on Orthopedic Infections, J. Arthroplasty, 34, S75–S84, 2019. 
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Short summary
Despite potential pharmacokinetic advantages, the local application of antibiotics in the treatment of periprosthetic joint infections has so far been associated with bad outcomes. This study shows a major advantage for the local application of antibiotics with calcium sulfate as the carrier material in the implant-retaining treatment of a periprosthetic joint infection of the hip.