Articles | Volume 6, issue 4
https://doi.org/10.5194/jbji-6-99-2021
https://doi.org/10.5194/jbji-6-99-2021
Original full-length article
 | 
12 Feb 2021
Original full-length article |  | 12 Feb 2021

Vancomycin bone and tissue concentrations following tibial intraosseous administration – evaluated in a porcine model

Josephine Olsen Kipp, Pelle Hanberg, Josefine Slater, Line Møller Nielsen, Stig Storgaard Jakobsen, Maiken Stilling, and Mats Bue

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Cited articles

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Bue, M., Birke-Sorensen, H., Thillemann, T. M., Hardlei, T. F., Soballe, K., and Tottrup, M.: Single-dose pharmacokinetics of vancomycin in porcine cancellous and cortical bone determined by microdialysis, Int. J. Antimicrob. Ag., 46, 434–438, https://doi.org/10.1016/j.ijantimicag.2015.06.014, 2015. 
Bue, M., Tottrup, M., Hanberg, P., Langhoff, O., Birke-Sorensen, H., Thillemann, T. M., Andersson, T. L., and Soballe, K.: Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients, Acta Orthop., 89, 95–100, https://doi.org/10.1080/17453674.2017.1373497, 2017. 
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Short summary
To evaluate bone and tissue concentrations following intraosseous vancomycin administration, eight pigs were injected with 500 mg vancomycin into the tibia followed by a 12 h sampling period. This provided high concentrations in the tibia bone nearby the injection site the entire period, though with a wide range of peak concentration. The systemic absorption was high and immediate, thus mirroring an intravenous administration. Low mean concentrations were found in adjacent tissue compartments.