Articles | Volume 6, issue 4
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Vancomycin bone and tissue concentrations following tibial intraosseous administration – evaluated in a porcine model
Josephine Olsen Kipp
CORRESPONDING AUTHOR
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Pelle Hanberg
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Department of Orthopaedic Surgery, Horsens Regional Hospital, Sundvej
30, 8700 Horsens, Denmark
Josefine Slater
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Line Møller Nielsen
Department of Clinical Biochemistry, Aarhus University Hospital,
Palle Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Stig Storgaard Jakobsen
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Department of Orthopaedic Surgery, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Maiken Stilling
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Department of Orthopaedic Surgery, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Orthopaedic Research Unit, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
Department of Orthopaedic Surgery, Aarhus University Hospital, Palle
Juul-Jensens Blvd. 99, 8200 Aarhus N, Denmark
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Mads Kristian Duborg Mikkelsen, Andrea René Jørgensen, Niranjan G. Kotla, Maiken Stilling, Maria Bech Damsgaard, Christoph Crocoll, Michal Poborsky, Hans Christian Rasmussen, Jonas Rosager Henriksen, Anders Elias Hansen, and Mats Bue
J. Bone Joint Infect., 10, 327–334, https://doi.org/10.5194/jbji-10-327-2025, https://doi.org/10.5194/jbji-10-327-2025, 2025
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In recent decades, there has been a growing emphasis on the use of local antibiotics in orthopaedic surgery, but development of new technologies has been limited. In this study we observe that a 1.5 mL injection of the novel technology CarboCell G/C into the bone provides very high levels of the antibiotics gentamicin and clindamycin in bones, with almost no spill to the bloodstream. These findings bolster the prospect of new and improved technologies for combatting orthopaedic infections.
Louise Kruse Jensen, Thomas Bjarnsholt, Hans Gottlieb, and Mats Bue
J. Bone Joint Infect., 10, 1–5, https://doi.org/10.5194/jbji-10-1-2025, https://doi.org/10.5194/jbji-10-1-2025, 2025
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To improve the existing knowledge and treatment of bone and joint infections, it is essential to unite medical disciplines and bridge the gap between basic and clinical sciences. In 2018, the Centrum fOr translational Medicine on Bone and joint INfEctions (COMBINE) was created to facilitate collaboration among Danish scientists and researchers dedicated to bone and joint infection research. This paper aims to share the COMBINE approach and values.
Rehne Lessmann Hansen, Mats Bue, Anna Bertoli Borgognoni, and Klaus Kjær Petersen
J. Bone Joint Infect., 7, 35–42, https://doi.org/10.5194/jbji-7-35-2022, https://doi.org/10.5194/jbji-7-35-2022, 2022
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This study consists of 26 patients with infection of the pubic symphysis. The authors believe that by drawing awareness to this condition patients may be diagnosed and undergo surgery faster; 21 of the patients had pelvic surgery before onset of pubic infection. The diagnostic delay was between 1 and 12 months. All patients underwent surgical debridement and received a minimum of 6 weeks antibiotic treatment; 23 patients had postoperative pain relief and 19 patients were ambulant without aids.
Mats Bue, Arnar Óskar Bjarnason, Jan Duedal Rölfing, Karina Larsen, and Juozas Petruskevicius
J. Bone Joint Infect., 6, 135–140, https://doi.org/10.5194/jbji-6-135-2021, https://doi.org/10.5194/jbji-6-135-2021, 2021
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In order to monitor pin site infections, facilitate communication between team members, and assist treatment decision-making, we aimed to develop a registration tool. The present pilot study evaluates the feasibility of a prospective registration procedure for reporting, evaluating, and monitoring of pin site infections in 39 trauma, limb deformity, and bone infection patients with external ring fixation.
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Short summary
To evaluate bone and tissue concentrations following intraosseous vancomycin administration, eight pigs were injected with 500 mg vancomycin into the tibia followed by a 12 h sampling period. This provided high concentrations in the tibia bone nearby the injection site the entire period, though with a wide range of peak concentration. The systemic absorption was high and immediate, thus mirroring an intravenous administration. Low mean concentrations were found in adjacent tissue compartments.
To evaluate bone and tissue concentrations following intraosseous vancomycin administration,...