Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 4
Articles | Volume 6, issue 4
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 4
Original full-length article
 | 
12 Feb 2021
Original full-length article |  | 12 Feb 2021

Vancomycin bone and tissue concentrations following tibial intraosseous administration – evaluated in a porcine model

Josephine Olsen Kipp, Pelle Hanberg, Josefine Slater, Line Møller Nielsen, Stig Storgaard Jakobsen, Maiken Stilling, and Mats Bue

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Short summary
To evaluate bone and tissue concentrations following intraosseous vancomycin administration, eight pigs were injected with 500 mg vancomycin into the tibia followed by a 12 h sampling period. This provided high concentrations in the tibia bone nearby the injection site the entire period, though with a wide range of peak concentration. The systemic absorption was high and immediate, thus mirroring an intravenous administration. Low mean concentrations were found in adjacent tissue compartments.
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