Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 4
Articles | Volume 6, issue 4
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-99-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 4
Original full-length article
 | 
12 Feb 2021
Original full-length article |  | 12 Feb 2021

Vancomycin bone and tissue concentrations following tibial intraosseous administration – evaluated in a porcine model

Josephine Olsen Kipp, Pelle Hanberg, Josefine Slater, Line Møller Nielsen, Stig Storgaard Jakobsen, Maiken Stilling, and Mats Bue

Viewed

Total article views: 988 (including HTML, PDF, and XML)
HTML PDF XML Total BibTeX EndNote
702 250 36 988 35 37
  • HTML: 702
  • PDF: 250
  • XML: 36
  • Total: 988
  • BibTeX: 35
  • EndNote: 37
Views and downloads (calculated since 12 Feb 2021)
Cumulative views and downloads (calculated since 12 Feb 2021)

Viewed (geographical distribution)

Total article views: 926 (including HTML, PDF, and XML) Thereof 926 with geography defined and 0 with unknown origin.
Country # Views %
  • 1
1
 
 
 
 

Cited

Latest update: 26 Apr 2024
Download
Short summary
To evaluate bone and tissue concentrations following intraosseous vancomycin administration, eight pigs were injected with 500 mg vancomycin into the tibia followed by a 12 h sampling period. This provided high concentrations in the tibia bone nearby the injection site the entire period, though with a wide range of peak concentration. The systemic absorption was high and immediate, thus mirroring an intravenous administration. Low mean concentrations were found in adjacent tissue compartments.
Read more