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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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We compared the outcome of bioactive glass S53P4 as bone substitute versus autologous bone grafts for filling defects in patients with infected non-union. Our comparison of the outcomes revealed no significant differences between the groups with respect to recurrence of infection, bone healing, full weight bearing, or complications in general. Our results are promising. BAG seems to be an appropriate bone substitute. Further studies with larger numbers of patients are required.
JBJI | Articles | Volume 6, issue 4
J. Bone Joint Infect., 6, 73–83, 2021
https://doi.org/10.5194/jbji-6-73-2021
J. Bone Joint Infect., 6, 73–83, 2021
https://doi.org/10.5194/jbji-6-73-2021

Original full-length article 12 Jan 2021

Original full-length article | 12 Jan 2021

Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions – a single center experience

Eva Steinhausen et al.

Cited articles

Auregan, J. C. and Begue, T.: Bioactive glass for long bone infection: a systematic review, Injury, 46, Suppl 8, S3–7, https://doi.org/10.1016/S0020-1383(15)30048-6, 2015. 
Bortolin, M., Romano, C. L., Bidossi, A., Vecchi, E., Mattina, R., and Drago, L.: BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria, Future Microbiol., 13, 525–533, https://doi.org/10.2217/fmb-2016-0171, 2018. 
Calori, G. M., Mazza, E., Colombo, M., and Ripamonti, C.: The use of bone-graft substitutes in large bone defects: any specific needs?, Injury, 42, Suppl 2, S56–63, https://doi.org/10.1016/j.injury.2011.06.011, 2011. 
Coraca-Huber, D. C., Fille, M., Hausdorfer, J., Putzer, D., and Nogler, M.: Efficacy of antibacterial bioactive glass S53P4 against S. aureus biofilms grown on titanium discs in vitro, J. Orthop. Res., 32, 175–177, https://doi.org/10.1002/jor.22463, 2014. 
Cunha, M. T., Murca, M. A., Nigro, S., Klautau, G. B., and Salles, M. J. C.: In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection, BMC Infect Dis., 18, 157, https://doi.org/10.1186/s12879-018-3069-x, 2018. 
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Short summary
We compared the outcome of bioactive glass S53P4 as bone substitute versus autologous bone grafts for filling defects in patients with infected non-union. Our comparison of the outcomes revealed no significant differences between the groups with respect to recurrence of infection, bone healing, full weight bearing, or complications in general. Our results are promising. BAG seems to be an appropriate bone substitute. Further studies with larger numbers of patients are required.
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