Articles | Volume 6, issue 9
https://doi.org/10.5194/jbji-6-433-2021
https://doi.org/10.5194/jbji-6-433-2021
Original full-length article
 | 
01 Dec 2021
Original full-length article |  | 01 Dec 2021

Immunological evaluation of patients with orthopedic infections: taking the Cierny–Mader classification to the next level

Janet D. Conway, Vache Hambardzumyan, Nirav G. Patel, Shawn D. Giacobbe, and Martin G. Gesheff

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Cited articles

Al-Herz, W., Bousfiha, A., Casanova, J. L., Chatila, T., Conley, M. E., Cunningham-Rundles, C., Etzioni, A., Franco, J. L., Gaspar, H. B., Holland, S. M., Klein, C., Nonoyama, S., Ochs, H. D., Oksenhendler, E., Picard, C., Puck, J. M., Sullivan, K., and Tang, M. L.: Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency, Front. Immunol., 5, 162, https://doi.org/10.3389/fimmu.2014.00162, 2014. 
Beard, L. J., Ferris, L., and Ferrante, A.: Immunoglobulin G subclasses and lymphocyte subpopulations and function in osteomyelitis and septic arthritis, Acta Paediatr. Scand., 79, 599–604, https://doi.org/10.1111/j.1651-2227.1990.tb11523.x, 1990. 
Bloom, K. A., Chung, D., and Cunningham-Rundles, C.: Osteoarticular infectious complications in patients with primary immunodeficiencies, Curr. Opin. Rheumatol., 20, 480–485, https://doi.org/10.1097/BOR.0b013e3282fd6e70, 2008. 
Bonilla, F. A., Barlan, I., Chapel, H., Costa-Carvalho, B. T., Cunningham-Rundles, C., de la Morena, M. T., Espinosa-Rosales, F. J., Hammarström, L., Nonoyama, S., Quinti, I., Routes, J. M., Tang, M. L., and Warnatz, K.: International consensus document (ICON): common variable immunodeficiency disorders, J. Allergy. Clin. Immunol. Pract., 4, 38–59, https://doi.org/10.1016/j.jaip.2015.07.025, 2016. 
Boyle, J. M. and Buckley R. H.: Population prevalence of diagnosed primary immunodeficiency diseases in the United States, J. Clin. Immunol., 27, 497–502, https://doi.org/10.1007/s10875-007-9103-1, 2007. 
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Short summary
Adding immunologic evaluation to the Cierny–Mader classification more accurately determines patients’ true host status and better quantifies risk and outcome with respect to orthopedic infection. Immunologically deficient A hosts should be quantified as B hosts. IgG deficiencies can be addressed with supplementation. IgG replacement should be considered in patients with recurrent orthopedic infections.