Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 9
Articles | Volume 6, issue 9
https://doi.org/10.5194/jbji-6-433-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-433-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 9
Original full-length article
 | 
01 Dec 2021
Original full-length article |  | 01 Dec 2021

Immunological evaluation of patients with orthopedic infections: taking the Cierny–Mader classification to the next level

Janet D. Conway, Vache Hambardzumyan, Nirav G. Patel, Shawn D. Giacobbe, and Martin G. Gesheff

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Latest update: 16 Oct 2025
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Short summary
Adding immunologic evaluation to the Cierny–Mader classification more accurately determines patients’ true host status and better quantifies risk and outcome with respect to orthopedic infection. Immunologically deficient A hosts should be quantified as B hosts. IgG deficiencies can be addressed with supplementation. IgG replacement should be considered in patients with recurrent orthopedic infections.
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