Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 6, issue 7
Articles | Volume 6, issue 7
https://doi.org/10.5194/jbji-6-313-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-313-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 7
Original full-length article
 | 
17 Aug 2021
Original full-length article |  | 17 Aug 2021

The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus

Karel-Jan Dag François Lensen, Rosa Escudero-Sanchez, Javier Cobo, Rihard Trebše, Camelia Gubavu, Sara Tedeschi, Jose M. Lomas, Cedric Arvieux, Dolors Rodriguez-Pardo, Massimo Fantoni, Maria Jose Garcia Pais, Francisco Jover, Mauro José Costa Salles, Ignacio Sancho, Marta Fernandez Sampedro, Alex Soriano, Marjan Wouthuyzen-Bakker, and ESCMID Study Group of Implant Associated Infections (ESGIAI)

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Escudero-Sanchez, R., Senneville, E., Digumber, M., Soriano, A., Del Toro, M. D., Bahamonde, A., Del Pozo, J. L., Guio, L., Murillo, O., Rico, A., García-País, M. J., Rodríguez-Pardo, D., Iribarren, J. A., Fernández, M., Benito, N., Fresco, G., Muriel, A., Ariza, J., and Cobo, J.: Suppressive antibiotic therapy in prosthetic joint infections: amulticentre cohort study, Clin. Microbiol. Infect., 26, 499–505, 2020. 
Ferry, T., Batailler, C., Brosset, S., Kolenda, C., Goutelle, S., Sappey-Marinier, E., Josse, J., Laurent, F., Lustig, S., and Lyon BJI Study Group: Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach, SICOT-J, 6, 26, https://doi.org/10.1051/sicotj/2020021, 2020. 
Fischetti, V. A.: Development of phage lysins as novel therapeutics: A historical perspective, Viruses, 10, 310, https://doi.org/10.3390/v10060310, 2018. 
Fowler, V. G., Jr, Das, A. F., Lipka-Diamond, J., Schuch, R., Pomerantz, R., Jáuregui-Peredo, L., Bressler, A., Evans, D., Moran, G. J., Rupp, M. E., Wise, R., Corey, G. R., Zervos, M., Douglas, P. S., and Cassino, C.: Exebacase (Lysin CF-301) improved clinical responder rates in methicillin resistant Staphylococcus aureus bacteremia including endocarditis compared to standard of care antibiotics alone in a first-in patient phase 2 study, in: European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam. Abstract L0012, 2019. 
Lensen, K.-J., Escudero-Sanchez, R., Cobo, J., Soriano, A., and Wouthuyzen-Bakker, M.: Chronic prosthetic joint infections with a draining sinus. Who should receive suppressive antibiotic treatment?, J. Bone Joint Infect., 6, 43–45, https://doi.org/10.5194/jbji-6-43-2020, 2020. 
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Our data suggest that, in periprosthetic joint infection (PJI) patients with a draining sinus, suppressive antibiotic treatment (SAT) can be considered on an individual basis. SAT may reduce pain and favour the closure of the sinus tract in certain individuals, but the prescription of SAT does not appear to have any influence on the prevention of prosthetic loosening and other infectious complications.
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