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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Our data suggest that, in periprosthetic joint infection (PJI) patients with a draining sinus, suppressive antibiotic treatment (SAT) can be considered on an individual basis. SAT may reduce pain and favour the closure of the sinus tract in certain individuals, but the prescription of SAT does not appear to have any influence on the prevention of prosthetic loosening and other infectious complications.
JBJI | Articles | Volume 6, issue 7
J. Bone Joint Infect., 6, 313–319, 2021
https://doi.org/10.5194/jbji-6-313-2021
J. Bone Joint Infect., 6, 313–319, 2021
https://doi.org/10.5194/jbji-6-313-2021

Original full-length article 17 Aug 2021

Original full-length article | 17 Aug 2021

The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus

Karel-Jan Dag François Lensen et al.

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Chronic prosthetic joint infections with a draining sinus. Who should receive suppressive antibiotic treatment?
Karel-Jan Lensen, Rosa Escudero-Sanchez, Javier Cobo, Alex Soriano, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 6, 43–45, https://doi.org/10.5194/jbji-6-43-2020,https://doi.org/10.5194/jbji-6-43-2020, 2020

Cited articles

Ferry, T., Batailler, C., Brosset, S., Kolenda, C., Goutelle, S., Sappey-Marinier, E., Josse, J., Laurent, F., Lustig, S., and Lyon BJI Study Group: Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach, SICOT-J, 6, 26, https://doi.org/10.1051/sicotj/2020021, 2020. 
Fischetti, V. A.: Development of phage lysins as novel therapeutics: A historical perspective, Viruses, 10, 310, https://doi.org/10.3390/v10060310, 2018. 
Fowler, V. G., Jr, Das, A. F., Lipka-Diamond, J., Schuch, R., Pomerantz, R., Jáuregui-Peredo, L., Bressler, A., Evans, D., Moran, G. J., Rupp, M. E., Wise, R., Corey, G. R., Zervos, M., Douglas, P. S., and Cassino, C.: Exebacase (Lysin CF-301) improved clinical responder rates in methicillin resistant Staphylococcus aureus bacteremia including endocarditis compared to standard of care antibiotics alone in a first-in patient phase 2 study, in: European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam. Abstract L0012, 2019. 
Lensen, K.-J., Escudero-Sanchez, R., Cobo, J., Soriano, A., and Wouthuyzen-Bakker, M.: Chronic prosthetic joint infections with a draining sinus. Who should receive suppressive antibiotic treatment?, J. Bone Joint Infect., 6, 43–45, https://doi.org/10.5194/jbji-6-43-2020, 2020. 
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Short summary
Our data suggest that, in periprosthetic joint infection (PJI) patients with a draining sinus, suppressive antibiotic treatment (SAT) can be considered on an individual basis. SAT may reduce pain and favour the closure of the sinus tract in certain individuals, but the prescription of SAT does not appear to have any influence on the prevention of prosthetic loosening and other infectious complications.
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