Articles | Volume 6, issue 7
https://doi.org/10.5194/jbji-6-313-2021
https://doi.org/10.5194/jbji-6-313-2021
Original full-length article
 | 
17 Aug 2021
Original full-length article |  | 17 Aug 2021

The efficacy of suppressive antibiotic treatment in patients managed non-operatively for periprosthetic joint infection and a draining sinus

Karel-Jan Dag François Lensen, Rosa Escudero-Sanchez, Javier Cobo, Rihard Trebše, Camelia Gubavu, Sara Tedeschi, Jose M. Lomas, Cedric Arvieux, Dolors Rodriguez-Pardo, Massimo Fantoni, Maria Jose Garcia Pais, Francisco Jover, Mauro José Costa Salles, Ignacio Sancho, Marta Fernandez Sampedro, Alex Soriano, Marjan Wouthuyzen-Bakker, and ESCMID Study Group of Implant Associated Infections (ESGIAI)

Related authors

Debridement, antimicrobial therapy, and implant retention (DAIR) as curative surgical strategy for acute periprosthetic hip and knee infections: a summary of the position paper from the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Marjan Wouthuyzen-Bakker, Tristan Ferry, Willem J. Metsemakers, Martin Clauss, Alex Soriano, Rihard Trebse, and Ricardo Sousa
J. Bone Joint Infect., 10, 139–142, https://doi.org/10.5194/jbji-10-139-2025,https://doi.org/10.5194/jbji-10-139-2025, 2025
Short summary
Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Tristan Ferry, Ricardo Sousa, Alex Soriano, Willem J. Metsemakers, Martin Clauss, Rihard Trebse, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 10, 101–138, https://doi.org/10.5194/jbji-10-101-2025,https://doi.org/10.5194/jbji-10-101-2025, 2025
Short summary
Postoperative antibiotic treatment does not lower re-revision rate in presumed aseptic hip and knee revision arthroplasties with unexpected positive intraoperative cultures – a matched cohort study
Sebastian Simon, Marjan Wouthuyzen-Bakker, Susana Gardete Hartmann, Jennyfer A. Mitterer, Sujeesh Sebastian, Stephanie Huber, Bernhard J. H. Frank, and Jochen G. Hofstaetter
J. Bone Joint Infect., 10, 51–59, https://doi.org/10.5194/jbji-10-51-2025,https://doi.org/10.5194/jbji-10-51-2025, 2025
Short summary
Synovial glucose and serum-to-synovial-glucose ratio perform better than other biomarkers for the diagnosis of acute postoperative prosthetic knee infection
Marta Sabater-Martos, Oscar Garcia, Laia Boadas, Laura Morata, Alex Soriano, and Juan Carlos Martínez-Pastor
J. Bone Joint Infect., 10, 41–49, https://doi.org/10.5194/jbji-10-41-2025,https://doi.org/10.5194/jbji-10-41-2025, 2025
Short summary
A combined debridement, antibiotics, and implant retention (DAIR) procedure with flap coverage for acute soft tissue defects following total knee arthroplasty: a retrospective study
Laia Boadas-Gironès, Marta Sabater-Martos, Marc Ferrer-Banus, Àlex Soriano-Viladomiu, and Juan Carlos Martínez-Pastor
J. Bone Joint Infect., 9, 241–248, https://doi.org/10.5194/jbji-9-241-2024,https://doi.org/10.5194/jbji-9-241-2024, 2024
Short summary

Cited articles

Ferry, T., Batailler, C., Brosset, S., Kolenda, C., Goutelle, S., Sappey-Marinier, E., Josse, J., Laurent, F., Lustig, S., and Lyon BJI Study Group: Medical innovations to maintain the function in patients with chronic PJI for whom explantation is not desirable: a pathophysiology-, multidisciplinary-, and experience-based approach, SICOT-J, 6, 26, https://doi.org/10.1051/sicotj/2020021, 2020. 
Fischetti, V. A.: Development of phage lysins as novel therapeutics: A historical perspective, Viruses, 10, 310, https://doi.org/10.3390/v10060310, 2018. 
Fowler, V. G., Jr, Das, A. F., Lipka-Diamond, J., Schuch, R., Pomerantz, R., Jáuregui-Peredo, L., Bressler, A., Evans, D., Moran, G. J., Rupp, M. E., Wise, R., Corey, G. R., Zervos, M., Douglas, P. S., and Cassino, C.: Exebacase (Lysin CF-301) improved clinical responder rates in methicillin resistant Staphylococcus aureus bacteremia including endocarditis compared to standard of care antibiotics alone in a first-in patient phase 2 study, in: European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam. Abstract L0012, 2019. 
Lensen, K.-J., Escudero-Sanchez, R., Cobo, J., Soriano, A., and Wouthuyzen-Bakker, M.: Chronic prosthetic joint infections with a draining sinus. Who should receive suppressive antibiotic treatment?, J. Bone Joint Infect., 6, 43–45, https://doi.org/10.5194/jbji-6-43-2020, 2020. 
Download
Short summary
Our data suggest that, in periprosthetic joint infection (PJI) patients with a draining sinus, suppressive antibiotic treatment (SAT) can be considered on an individual basis. SAT may reduce pain and favour the closure of the sinus tract in certain individuals, but the prescription of SAT does not appear to have any influence on the prevention of prosthetic loosening and other infectious complications.
Share