Articles | Volume 6, issue 6
https://doi.org/10.5194/jbji-6-189-2021
https://doi.org/10.5194/jbji-6-189-2021
Review
 | 
26 May 2021
Review |  | 26 May 2021

Pursuit of the ideal antiseptic irrigation solution in the management of periprosthetic joint infections

Ahmed Siddiqi, Zuhdi E. Abdo, Bryan D. Springer, and Antonia F. Chen

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Cited articles

Bactisure™: Surgical Lavage – NextScience, available at: https://www.nextscience.com/bactisure-surgical-lavage/, last access: 6 January 2021. 
Barros, L. H., Barbosa, T. A., Esteves, J., Abreu, M., Soares, D., and Sousa, R.: Early Debridement, antibiotics and implant retention (DAIR) in patients with suspected acute infection after hip or knee arthroplasty – safe, effective and without negative functional impact, J. Bone Joint Infect., 4, 300–305, https://doi.org/10.7150/jbji.39168, 2019. 
B. Braun: Prontosan® Irrigation Solution, available at: https://www.bbraunusa.com/en/products/b4/prontosan-irrigationsolution.html, last access: 1 May 2021. 
Block, M. S. and Rowan, B. G.: Hypochlorous acid: a review, J. Oral Maxillofacial Surg., 78, 1461–1466, 2020. 
Blom, A., Cho, J., Fleischman, A., Goswami, K., Ketonis, C., Kunutsor, S. K., Makar, G., Meeker, D. G., Morgan-Jones, R., Ortega-Peña, S., Parvizi, J., Smeltzer, M., Stambough, J. B., Urish, K., and Ziliotto, G.: General Assembly, Prevention, Antiseptic Irrigation Solution: Proceedings of International Consensus on Orthopedic Infections, J. Arthroplasty, 34, S131–S138, 2019. 
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Short summary
Irrigation and debridement in the treatment of periprosthetic joint infection (PJI) serves an integral role in the eradication of bacterial burden and subsequent re-infection rates. Identifying the optimal irrigation agent, however, remains challenging, as there is limited data on superiority. Future clinical studies are needed to identify ideal irrigation solutions with optimal bactericidal properties and low cytotoxicity for PJI treatment.