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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Antibiotics are frequently used in bone cement during joint replacements or treatment of bone and joint infections. Amikacin is rarely used in bone cement, particularly the liquid formulation. We describe a series of patients in which liquid amikacin was incorporated into bone cement. We did not observe the occurrence of adverse drug reactions definitively attributed to its use. All patients had favorable outcomes.
JBJI | Articles | Volume 6, issue 5
J. Bone Joint Infect., 6, 147–150, 2021
https://doi.org/10.5194/jbji-6-147-2021
J. Bone Joint Infect., 6, 147–150, 2021
https://doi.org/10.5194/jbji-6-147-2021

Brief report 26 Apr 2021

Brief report | 26 Apr 2021

Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement – a case series

Don Bambino Geno Tai et al.

Cited articles

Anagnostakos, K. and Meyer, C.: Antibiotic Elution from Hip and Knee Acrylic Bone Cement Spacers: A Systematic Review, BioMed Res. Int., 2017, 4657874, https://doi.org/10.1155/2017/4657874, 2017. 
Athans, V., Veve, M. P., and Davis, S. L.: Trowels and Tribulations: Review of Antimicrobial-Impregnated Bone Cements in Prosthetic Joint Surgery, Pharmacotherapy, J. Human Pharmacol. Drug Ther., 37, 1565–1577, https://doi.org/10.1002/phar.2040, 2017. 
Chang, Y. H., Tai, C. L., Hsu, H. Y., Hsieh, P. H., Lee, M. S., and Ueng, S. W.: Liquid antibiotics in bone cement: an effective way to improve the efficiency of antibiotic release in antibiotic loaded bone cement, Bone Joint Res., 3, 246–251, https://doi.org/10.1302/2046-3758.38.2000305, 2014. 
Ethell, M. T., Bennett, R. A., Brown, M. P., Merritt, K., Davidson, J. S., and Tran, T.: In Vitro Elution of Gentamicin, Amikacin, and Ceftiofur From Polymethylmethacrylate and Hydroxyapatite Cement, Vet. Surg., 29, 375–382, https://doi.org/10.1053/jvet.2000.7535, 2000.  
Goldstein, N., St. Clair, J. B., Kasperbauer, S. H., Daley, C. L., and Lindeque, B.: Nontuberculous Mycobacterial Musculoskeletal Infection Cases from a Tertiary Referral Center, Colorado, USA, Emerg. Infect. Dis., 25, 1075–1083, https://doi.org/10.3201/eid2406.181041, 2019. 
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Short summary
Antibiotics are frequently used in bone cement during joint replacements or treatment of bone and joint infections. Amikacin is rarely used in bone cement, particularly the liquid formulation. We describe a series of patients in which liquid amikacin was incorporated into bone cement. We did not observe the occurrence of adverse drug reactions definitively attributed to its use. All patients had favorable outcomes.
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