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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Bacterial biofilm infections of artificial knees are treated by mixing antibiotics into bone cement and calcium sulfate beads. We designed a knee size model to show that cement alone killed biofilms on orthopedic materials and prevented their spread close to the cement, but adding beads significantly killed biofilms further away. The model is useful in helping show how both the spread and the amount of antibiotic carrier can kill biofilms that might be in different places in the joint.
JBJI | Articles | Volume 6, issue 5
J. Bone Joint Infect., 6, 119–129, 2021
https://doi.org/10.5194/jbji-6-119-2021
J. Bone Joint Infect., 6, 119–129, 2021
https://doi.org/10.5194/jbji-6-119-2021

Original full-length article 23 Mar 2021

Original full-length article | 23 Mar 2021

Pseudomonas aeruginosa biofilm killing beyond the spacer by antibiotic-loaded calcium sulfate beads: an in vitro study

Jacob R. Brooks et al.

Cited articles

Abosala, A. and Ali, M.: The Use of Calcium Sulphate beads in Periprosthetic Joint Infection, a systematic review, J. Bone Joint Infect., 5, 43–49, https://doi.org/10.7150/jbji.41743, 2020. 
Anagnostakos, K.: Therapeutic Use of Antibiotic-loaded Bone Cement in the Treatment of Hip and Knee Joint Infections, J. Bone Joint Infect., 2, 29–37, https://doi.org/10.7150/jbji.16067, 2017. 
Boddapati, V., Fu, M. C., Mayman, D. J., Su, E. P., Sculco, P. K., and McLawhorn, A. S.: Revision Total Knee Arthroplasty for Periprosthetic Joint Infection Is Associated With Increased Postoperative Morbidity and Mortality Relative to Noninfectious Revisions, J. Arthroplasty, 33, 521–526, https://doi.org/10.1016/j.arth.2017.09.021, 2018. 
Choi, H. R., Kwon, Y. M., Freiberg, A. A., Nelson, S. B., and Malchau, H.: Periprosthetic joint infection with negative culture results: Clinical characteristics and treatment outcome, J. Arthroplasty, 28, 899–903, https://doi.org/10.1016/j.arth.2012.10.022, 2013. 
Ciofu, O., Rojo-Molinero, E., Macià, M. D., and Oliver, A.: Antibiotic treatment of biofilm infections, APMIS, 125, 304–319, https://doi.org/10.1111/apm.12673, 2017. 
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Short summary
Bacterial biofilm infections of artificial knees are treated by mixing antibiotics into bone cement and calcium sulfate beads. We designed a knee size model to show that cement alone killed biofilms on orthopedic materials and prevented their spread close to the cement, but adding beads significantly killed biofilms further away. The model is useful in helping show how both the spread and the amount of antibiotic carrier can kill biofilms that might be in different places in the joint.
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