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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Bacterial biofilm infections of artificial knees are treated by mixing antibiotics into bone cement and calcium sulfate beads. We designed a knee size model to show that cement alone killed biofilms on orthopedic materials and prevented their spread close to the cement, but adding beads significantly killed biofilms further away. The model is useful in helping show how both the spread and the amount of antibiotic carrier can kill biofilms that might be in different places in the joint.
JBJI | Articles | Volume 6, issue 5
J. Bone Joint Infect., 6, 119–129, 2021
https://doi.org/10.5194/jbji-6-119-2021
J. Bone Joint Infect., 6, 119–129, 2021
https://doi.org/10.5194/jbji-6-119-2021

Original full-length article 23 Mar 2021

Original full-length article | 23 Mar 2021

Pseudomonas aeruginosa biofilm killing beyond the spacer by antibiotic-loaded calcium sulfate beads: an in vitro study

Jacob R. Brooks et al.

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Short summary
Bacterial biofilm infections of artificial knees are treated by mixing antibiotics into bone cement and calcium sulfate beads. We designed a knee size model to show that cement alone killed biofilms on orthopedic materials and prevented their spread close to the cement, but adding beads significantly killed biofilms further away. The model is useful in helping show how both the spread and the amount of antibiotic carrier can kill biofilms that might be in different places in the joint.
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