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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 3, issue 1
J. Bone Joint Infect., 3, 1–4, 2018
https://doi.org/10.7150/jbji.22459
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 3, 1–4, 2018
https://doi.org/10.7150/jbji.22459
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Brief report 01 Jan 2018

Brief report | 01 Jan 2018

Staphylococcus epidermidis isolates from nares and prosthetic joint infections are mupirocin susceptible

Lavin Salih1, Staffan Tevell1,2, Emeli Månsson1,3, Åsa Nilsdotter-Augustinsson4, Bengt Hellmark1, and Bo Söderquist1 Lavin Salih et al.
  • 1School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
  • 2Department of Infectious Diseases, Karlstad Hospital, Sweden
  • 3RegionVästmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland, Västerås, Sweden
  • 4Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, and Department of Infectious Diseases, County Council of Östergötland, Linköping, Sweden

Keywords: Staphylococcus epidermidis, Prosthetic joint infections, Mupirocin, Antibiotic susceptibility testing

Abstract. The objective of the present study was to investigate the antibiotic susceptibility including mupirocin among Staphylococcus. epidermidis isolated from prosthetic joint infections (PJIs) (n=183) and nasal isolates (n=75) from patients intended to undergo prosthetic joint replacements. Susceptibility to mupirocin (used for eradication of nasal carriership of Staphylococcus aureus) was investigated by gradient test, and susceptibility to various other antimicrobial agents was investigated by disc diffusion test. All isolates, except three from PJIs and one from the nares, were fully susceptible to mupirocin. Multi-drug resistance (≥3 antibiotic classes) was found in 154/183 (84.2%) of the PJI isolates but only in 2/75 (2.7%) of the nares isolates, indicating that S. epidermidis causing PJIs do not originate from the nares.

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