JBJI Journal of Bone and Joint Infection JBJI J. Bone Joint Infect. 2206-3552 Ivyspring Göttingen, Germany 10.7150/jbji.22459 <em>Staphylococcus epidermidis</em> isolates from nares and prosthetic joint infections are mupirocin susceptible Salih Lavin 1 Tevell Staffan 1 2 Månsson Emeli 1 3 Nilsdotter-Augustinsson Åsa 4 Hellmark Bengt 1 Söderquist Bo 1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden Department of Infectious Diseases, Karlstad Hospital, Sweden RegionVästmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland, Västerås, Sweden Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, and Department of Infectious Diseases, County Council of Östergötland, Linköping, Sweden 01 01 2018 3 1 1 4 Copyright: © 2018 Lavin Salih et al. 2018 This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ This article is available from https://jbji.copernicus.org/articles/3/1/2018/jbji-3-1-2018.html The full text article is available as a PDF file from https://jbji.copernicus.org/articles/3/1/2018/jbji-3-1-2018.pdf

<p class="p p-first-last" id="__p2">The objective of the present study was to investigate the antibiotic susceptibility including mupirocin among <em>Staphylococcus. epidermidis</em> isolated from prosthetic joint infections (PJIs) (n=183) and nasal isolates (n=75) from patients intended to undergo prosthetic joint replacements. Susceptibility to mupirocin (used for eradication of nasal carriership of <em>Staphylococcus aureus</em>) was investigated by gradient test, and susceptibility to various other antimicrobial agents was investigated by disc diffusion test. All isolates, except three from PJIs and one from the nares, were fully susceptible to mupirocin. Multi-drug resistance (≥3 antibiotic classes) was found in 154/183 (84.2%) of the PJI isolates but only in 2/75 (2.7%) of the nares isolates, indicating that <em>S. epidermidis</em> causing PJIs do not originate from the nares.</p>

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