Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 1
Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-95-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-95-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 1
Original full-length article
 | 
10 Feb 2026
Original full-length article |  | 10 Feb 2026

Safety of locally applied antibiotics in orthopaedic trauma surgery: descriptive results from a prospective cohort study

Niels Vanvelk, Esther M. M. Van Lieshout, Leendert H. T. Nugteren, A. Cornelis Plaisier, Rosalya Van der Pot, Corine Bethlehem, Willem-Jan Metsemakers, William T. Obremskey, and Michael H. J. Verhofstad

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Short summary
Although local antibiotic administration is used to prevent and treat fracture-related infections, concerns remain about systemic absorption and potential renal toxicity. This study assessed serum levels and renal function after local gentamicin or vancomycin use. Gentamicin exceeded the lower limit of quantification in 17% of cases but remained below toxic levels. Vancomycin was undetectable. These findings suggest that local antibiotic administration does not harm renal function.
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