Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 5
Articles | Volume 11, issue 5
https://doi.org/10.5194/jbji-11-565-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-565-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 5
Case report
 | 
10 Sep 2026
Case report |  | 10 Sep 2026

Clinical case of polymicrobial and multidrug-resistant posttraumatic chronic hip infection treatment

Urban Vadnjal, Samo Roškar, René Mihalič, Mitja Rak, and Rihard Trebše

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Cited articles

Aparicio-Blanco, J., Vishwakarma, N., Lehr, C. M., Prestidge, C. A., Thomas, N., Roberts, R. J., Thorn, C. R., and Melero, A.: Antibiotic resistance and tolerance: what can drug delivery do against this global threat?, Drug Deliv. Transl. Res., 14, 1725–1734, https://doi.org/10.1007/s13346-023-01513-6, 2024. 
Hantouly, A. T., Lawand, J., Alzobi, O., Hoveidaei, A. H., Salman, L. A., Hameed, S., Ahmed, G., and Citak, M.: High mortality rate and restricted mobility in above knee amputation following periprosthetic joint infection after total knee arthroplasty: a systematic review, Arch. Orthop. Trauma Surg., 144, 5273–5282, https://doi.org/10.1007/s00402-024-05578-x, 2024.  
Macià, M. D., Rojo-Molinero, E., and Oliver, A.: Antimicrobial susceptibility testing in biofilm-growing bacteria, Clin. Microbiol. Infect., 20, 981–990, https://doi.org/10.1111/1469-0691.12651, 2014. 
McNally, M., Sousa, R., Wouthuyzen-Bakker, M., Chen, A. F., Soriano, A., Vogely, H. C., Clauss, M., Higuera, C. A., and Trebše, R.: The EBJIS definition of periprosthetic joint infection, Bone Joint J., 103-B, 18–25, https://doi.org/10.1302/0301-620X.103B1.BJJ-2020-1381.R1, 2021. 
Mian, H. M., Lyons, J. G., Perrin, J., Froehle, A. W., and Krishnamurthy, A. B.: A review of current practices in periprosthetic joint infection debridement and revision arthroplasty, Arthroplasty, 4, 31, https://doi.org/10.1186/s42836-022-00136-5, 2022. 
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The case demonstrates the importance of having well-established hospital algorithms for fracture related infection (FRI)/periprosthetic
joint infection (PJI) treatment and strictly following them at each step. In most severe cases related to multidrug-resistant (MDR) bacteria, a multiple-stage protocol is indicated, and intra-articular infusions of antibiotics should be considered in addition to standard intravenous regimens.
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