Articles | Volume 11, issue 4
https://doi.org/10.5194/jbji-11-453-2026
https://doi.org/10.5194/jbji-11-453-2026
Original full-length article
 | 
31 Jul 2026
Original full-length article |  | 31 Jul 2026

Rapid molecular culture versus conventional culture for periprosthetic joint infection: diagnostic performance and clinical relevance

Elizabeth Morreel, Paul Savelkoul, and Inge van Loo

Cited articles

Alt, V., Szymski, D., Rupp, M., Fontalis, A., Vaznaisiene, D., Marais, L. C., Wagner, C., and Walter, N.: The health-economic burden of hip and knee periprosthetic joint infections in Europe, Bone Joint Open, 6, 298–311, https://doi.org/10.1302/2633-1462.63.bjo-2024-0225.r1, 2025. 
Bos, M. P., van Houdt, R., Poort, L., van der Stel, A. X., Peters, E. J., Saouti, R., Savelkoul, P., and Budding, A. E.: Rapid Diagnostics of Joint Infections Using IS-Pro, J. Clin. Microbiol., 61, e0015423, https://doi.org/10.1128/jcm.00154-23, 2023. 
Diep, C., Jaffe, R., Witiw, C., Daza, J. F., Wijeysundera, D. N., Ravi, B., and Ladha, K. S.: Impact of major postoperative complications on employment and earnings after elective hip or knee replacement surgery: a population-based matched cohort study, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, https://doi.org/10.1007/s12630-025-02960-0, 2025. 
Dutch Arthroplasty Register (LROI): Online LROI annual report 2024, https://www.lroi.nl/media/prqogokg/pdf-lroi-report-2024.pdf/ (last access: 8 January 2026), 2024. 
Esteban, J., Patel, R., Aguilera-Correa, J. J., and Nelson, S. B.: Optimized use and performance of culture for periprosthetic joint infection diagnosis: a comprehensive literature review, Clin. Microbiol. Rev., 38, e0005425, https://doi.org/10.1128/cmr.00054-25, 2025. 
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Short summary
Joint replacement infections are difficult to diagnose quickly because standard laboratory cultures can take days to weeks and may miss bacteria after antibiotic treatment. We evaluated a rapid molecular test using fluid from removed implants and found that it provided clinically useful results within hours. This approach may help doctors exclude infection sooner, reduce unnecessary antibiotic use, and improve patient care.
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