Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 3
Articles | Volume 11, issue 3
https://doi.org/10.5194/jbji-11-257-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-257-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 3
Original full-length article
 | 
08 May 2026
Original full-length article |  | 08 May 2026

CarboCell G/C provides sustained high local bone antibiotic levels with minimal systemic exposure, supporting its therapeutic potential in orthopedic infection management

Nicole Lind Henriksen, Andrea René Jørgensen, Michal Poborsky, Christoph Crocoll, Niranjan G. Kotla, Catrine Jyde Berthelsen, Mats Bue, Louise Kruse Jensen, Anders Elias Hansen, and Jonas Rosager Henriksen

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Short summary
CarboCell is an injectable material designed to release antibiotics directly where bone infections occur. We tested it in animals and found that it delivered high and long-lasting drug levels in bone while keeping drug levels in the rest of the body very low. This suggests that CarboCell may improve infection treatment and reduce the need for whole-body antibiotic therapy.
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