Articles | Volume 11, issue 2
https://doi.org/10.5194/jbji-11-237-2026
https://doi.org/10.5194/jbji-11-237-2026
Original full-length article
 | 
21 Apr 2026
Original full-length article |  | 21 Apr 2026

Rifampin resistance and multidrug resistance or extensive drug resistance (MDR/XDR) predict failure in monomicrobial Staphylococcus epidermidis periprosthetic joint infection (PJI) – a 15-year single-center cohort study

Álvaro Auñon, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, and Jaime Esteban

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Cited articles

Ariza, J., Cobo, J., Baraia-Etxaburu, J., Benito, N., Bori, G., Cabo, J., Corona, P., Esteban, J., Horcajada, J. P., Lora-Tamayo, J., Murillo, O., Palomino, J., Parra, J., Pigrau, C., Del Pozo, J. L., Riera, M., Rodríguez, D., Sánchez-Somolinos, M., Soriano, A., Del Toro, M. D., and de la Torre, B.: Executive summary of management of prosthetic joint infections, Clinical practice guidelines by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Enferm. Infecc. Microbiol. Clin., 35, 189–195, https://doi.org/10.1016/j.eimc.2016.08.012, 2017. 
Auñón, Á., Tovar-Bazaga, M., Blanco-García, A., García-Cañete, J., Parrón, R., and Esteban, J.: Does a new antibiotic scheme improve the outcome of Staphylococcus aureus-caused acute prosthetic joint infections treated with debridement, antibiotics and implant retention (DAIR), Antibiotics, 11, 922, https://doi.org/10.3390/antibiotics11070922, 2022. 
Bart, G., Zeller, V., Kerroumi, Y., Heym, B., Meyssonnier, V., Desplaces, N., Kitzis, M. D., Ziza, J. M., and Marmor, S.: Minocycline Combined with Vancomycin for the Treatment of Methicillin-Resistant Coagulase-Negative Staphylococcal Prosthetic Joint Infection Managed with Exchange Arthroplasty, J. Bone Joint Infect., 5, 110–117, https://doi.org/10.7150/jbji.43254, 2020. 
Charalambous, L. T., Kim, B. I., Schwartz, A. M., Case, A., Seidelman, J. L., Hendershot, E. F., Bolognesi, M. P., Seyler, T. M., and Jiranek, W. A.: Prosthetic knee infection with coagulase-negative staphylococcus, a harbinger of poor outcomes, J. Arthroplasty, 37, S313–S320, https://doi.org/10.1016/j.arth.2022.02.050, 2022. 
Fillingham, Y. A., Della Valle, C. J., Suleiman, L. I., Springer, B. D., Gehrke, T., Bini, S. A., Segreti, J., Chen, A. F., Goswami, K., Tan, T. L., Shohat, N., Diaz-Ledezma, C., Schwartz, A. J., and Parvizi, J.: Definition of successful infection management and guidelines for reporting of outcomes after surgical treatment of periprosthetic joint infection, J. Bone Joint Surg. Am., 101, e69, https://doi.org/10.2106/JBJS.19.00062, 2019. 
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Short summary
We studied hip and knee prosthetic joint infections  caused by Staphylococcus epidermidis, a common pathogen that can form biofilm on implants. We reviewed over 100 cases to understand how antibiotic resistance affects treatment success. We found that infections resistant to rifampin, levofloxacin, or multiple antibiotics showed a higher failure rate. These findings may help surgeons choose the best surgical and antibiotic treatment approach for patients.
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