Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 2
Articles | Volume 11, issue 2
https://doi.org/10.5194/jbji-11-237-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-237-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 2
Original full-length article
 | 
21 Apr 2026
Original full-length article |  | 21 Apr 2026

Rifampin resistance and multidrug resistance or extensive drug resistance (MDR/XDR) predict failure in monomicrobial Staphylococcus epidermidis periprosthetic joint infection (PJI) – a 15-year single-center cohort study

Álvaro Auñon, Santiago Gabardo, Carmen Álvaro, Ricardo de la Concha, Javier Sanado, and Jaime Esteban

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Short summary
We studied hip and knee prosthetic joint infections  caused by Staphylococcus epidermidis, a common pathogen that can form biofilm on implants. We reviewed over 100 cases to understand how antibiotic resistance affects treatment success. We found that infections resistant to rifampin, levofloxacin, or multiple antibiotics showed a higher failure rate. These findings may help surgeons choose the best surgical and antibiotic treatment approach for patients.
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