Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 2
Articles | Volume 11, issue 2
https://doi.org/10.5194/jbji-11-229-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-229-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 2
Original full-length article
 | 
15 Apr 2026
Original full-length article |  | 15 Apr 2026

Empirical antibiotic therapy in acute orthopaedic infections: differences in antimicrobial susceptibility across anatomical sites

Yoni Lodewijk-van den Brink, Jon H. M. Goosen, Denise S. C. Telgt, Marrigje Nabuurs-Franssen, and Karin C. M. Veerman

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Short summary
Early postoperative orthopaedic infections require rapid empirical antibiotic treatment, but the optimal regimen may differ by anatomical site. In this retrospective cohort study, empirical coverage was evaluated across anatomical sites. Vancomycin combined with ceftriaxone provided high coverage for most sites, while foot and ankle infections showed higher rates of resistant Gram-negative bacteria. These findings support an anatomy-specific approach to treatment.
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