Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 2
Articles | Volume 11, issue 2
https://doi.org/10.5194/jbji-11-161-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-161-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 2
Original full-length article
 | 
12 Mar 2026
Original full-length article |  | 12 Mar 2026

Combined analysis of host immune response, biofilm genes, and 16S rRNA detection in fracture-related infection: an observational cohort study

Melissa Depypere, Jonathan Sliepen, Jolien Onsea, Yves Debaveye, T. Fintan Moriarty, Elena Della Bella, Emmanuel André, Johan Van Weyenbergh, and Willem-Jan Metsemakers

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Short summary
The aim of this proof-of-concept study was to investigate host immune gene expression through transcriptome profiling in patients with fracture-related infection and to explore the feasibility of detecting 16S rRNA and biofilm-associated genes, an approach not previously applied using this method. This technique revealed distinct immune activation patterns in fracture-related infection (FRI) and enabled the identification of pathogens that were missed by conventional culture techniques. 
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