Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 2
Articles | Volume 11, issue 2
https://doi.org/10.5194/jbji-11-149-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-149-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 2
Original full-length article
 | 
11 Mar 2026
Original full-length article |  | 11 Mar 2026

Advancing diagnostics in suspected periprosthetic joint infections using synthetic synovial fluid and microcalorimetry

Amber De Bleeckere, Jeroen Neyt, Jasper Van Heuverswyn, Stien Vandendriessche, Hannelore Hamerlinck, Annelynn Wallaert, Christophe Pattyn, Bruno Verhasselt, Jerina Boelens, and Tom Coenye

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Short summary
Timely and accurate pathogen identification is essential for managing periprosthetic joint infections (PJIs), yet conventional culturing often yields false negatives and requires prolonged incubation. We evaluated an in-vivo-like synovial fluid medium and isothermal microcalorimetry. The combined use of these approaches improved detection rates and reduced time to diagnosis, offering valuable insights to advance PJI diagnostics and support better clinical decision-making.
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