Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 11, issue 1
Articles | Volume 11, issue 1
https://doi.org/10.5194/jbji-11-113-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-11-113-2026
© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 11, issue 1
Original full-length article
 | 
12 Feb 2026
Original full-length article |  | 12 Feb 2026

Treatment of periprosthetic joint infection – outcomes following algorithm-guided treatment at a multidisciplinary referral centre

Christian Merz, Jan Klaas, Rik Osinga, Parham Sendi, Richard Alexander Kuehl, Mario Morgenstern, and Martin Clauss

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Alt, V., Szymski, D., Rupp, M., Fontalis, A., Vaznaisiene, D., Marais, L. C., Wagner, C., and Walter, N.: The health-economic burden of hip and knee periprosthetic joint infections in Europe, Bone Jt. Open, 6, 298–311, https://doi.org/10.1302/2633-1462.63.BJO-2024-0225.R1, 2025. 
Baertl, S., Lovasz, D., Kees, M. G., Walter, N., Schindler, M., Li, J., Reinhard, J., Alt, V., and Rupp, M.: Periprosthetic Joint Infection and Concomitant Sepsis: Unveiling Clinical Manifestations, Risk Factors, and Patient Outcomes, J. Arthroplasty, 40, 1827–1835, https://doi.org/10.1016/j.arth.2024.11.062, 2024. 
Barton, C. B., Wang, D. L., An, Q., Brown, T. S., Callaghan, J. J., and Otero, J. E.: Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection Following Total Hip or Knee Arthroplasty Is Associated With High Attrition Rate and Mortality, J. Arthroplasty, 35, 1384–1389, https://doi.org/10.1016/j.arth.2019.12.005, 2020. 
Born, P., Ilchmann, T., Zimmerli, W., Zwicky, L., Graber, P., Ochsner, P. E., and Clauss, M.: Eradication of infection, survival, and radiological results of uncemented revision stems in infected total hip arthroplasties: 28 one-stage and 53 two-stage exchanges with a mean follow-up of 7 years, Acta Orthop., 87, 637–643, https://doi.org/10.1080/17453674.2016.1237423, 2016. 
Clauss, M., Hunkeler, C., Manzoni, I., and Sendi, P.: Debridement, Antibiotics and Implant Retention for Hip Periprosthetic Joint Infection: Analysis of Implant Survival after Cure of Infection, J. Bone Jt. Infect., 5, 35–42, https://doi.org/10.7150/jbji.40924, 2020. 
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Founded in 2019, the Center for Musculoskeletal Infections at University Hospital Basel was established to implement standardized, multidisciplinary care for orthopaedic and trauma-related infections. This retrospective analysis of hip and knee periprosthetic joint infections (2019–2022) illustrates the feasibility and effectiveness of this structured approach, with infection control achieved in the majority of patients despite case complexity.
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