Treatment of periprosthetic joint infection –  outcomes following algorithm-guided treatment at a multidisciplinary referral centre

Merz, Christian; Klaas, Jan; Osinga, Rik; Sendi, Parham; Kuehl, Richard Alexander; Morgenstern, Mario; Clauss, Martin

doi:10.5194/jbji-11-113-2026

Articles | Volume 11, issue 1

https://doi.org/10.5194/jbji-11-113-2026

© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-11-113-2026

© Author(s) 2026. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 11, issue 1

Original full-length article

|

12 Feb 2026

Original full-length article |

| 12 Feb 2026

Treatment of periprosthetic joint infection – outcomes following algorithm-guided treatment at a multidisciplinary referral centre

Christian Merz, Jan Klaas, Rik Osinga, Parham Sendi, Richard Alexander Kuehl, Mario Morgenstern, and Martin Clauss

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Cited articles

Alt, V., Szymski, D., Rupp, M., Fontalis, A., Vaznaisiene, D., Marais, L. C., Wagner, C., and Walter, N.: The health-economic burden of hip and knee periprosthetic joint infections in Europe, Bone Jt. Open, 6, 298–311, https://doi.org/10.1302/2633-1462.63.BJO-2024-0225.R1, 2025.

Baertl, S., Lovasz, D., Kees, M. G., Walter, N., Schindler, M., Li, J., Reinhard, J., Alt, V., and Rupp, M.: Periprosthetic Joint Infection and Concomitant Sepsis: Unveiling Clinical Manifestations, Risk Factors, and Patient Outcomes, J. Arthroplasty, 40, 1827–1835, https://doi.org/10.1016/j.arth.2024.11.062, 2024.

Barton, C. B., Wang, D. L., An, Q., Brown, T. S., Callaghan, J. J., and Otero, J. E.: Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection Following Total Hip or Knee Arthroplasty Is Associated With High Attrition Rate and Mortality, J. Arthroplasty, 35, 1384–1389, https://doi.org/10.1016/j.arth.2019.12.005, 2020.

Born, P., Ilchmann, T., Zimmerli, W., Zwicky, L., Graber, P., Ochsner, P. E., and Clauss, M.: Eradication of infection, survival, and radiological results of uncemented revision stems in infected total hip arthroplasties: 28 one-stage and 53 two-stage exchanges with a mean follow-up of 7 years, Acta Orthop., 87, 637–643, https://doi.org/10.1080/17453674.2016.1237423, 2016.

Clauss, M., Hunkeler, C., Manzoni, I., and Sendi, P.: Debridement, Antibiotics and Implant Retention for Hip Periprosthetic Joint Infection: Analysis of Implant Survival after Cure of Infection, J. Bone Jt. Infect., 5, 35–42, https://doi.org/10.7150/jbji.40924, 2020.