Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 6
Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-553-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-553-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 6
Original full-length article
 | 
08 Dec 2025
Original full-length article |  | 08 Dec 2025

Clinical characteristics of culture-negative periprosthetic joint infections: findings from an international periprosthetic joint infection registry

Graham S. Goh, Elise R. Naufal, Michelle M. Dowsey, Sina Babazadeh, Jesse E. Otero, Carlos A. Higuera-Rueda, Marjan Wouthuyzen-Bakker, and Orthopaedic Device Infection Network (ODIN)

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Latest update: 10 Nov 2026
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Short summary

A multi-center study of 563 periprosthetic joint infections (PJIs) found that 16.5 % were culture negative. These patients more often had prior revision or PJI, longer symptom duration and fewer systemic signs. On multivariable analysis, symptom duration >12 weeks was the only independent risk factor (odds ratio 2.24). The findings support the fact that culture-negative infections present insidiously, informing diagnostic strategies.

 

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