Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-543-2025
https://doi.org/10.5194/jbji-10-543-2025
Original full-length article
 | 
05 Dec 2025
Original full-length article |  | 05 Dec 2025

Cause of death following revision for periprosthetic joint infection or major aseptic revision in total hip and knee arthroplasty

Nicolai Kjældgaard Kristensen, Per Hviid Gundtoft, Brian Elmengaard, Alma Becic Pedersen, and Jeppe Lange

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Early periprosthetic hip joint infection managed by cementless one-stage revision – a case series
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Short summary

Cited articles

Anneberg, M., Kristiansen, E. B., Troelsen, A., Gundtoft, P., Sorensen, H. T., and Pedersen, A. B.: Enhancing the data capture of periprosthetic joint infections in the Danish Knee Arthroplasty Registry: validity assessment and incidence estimation, Acta Orthop., 95, 166–173, https://doi.org/10.2340/17453674.2024.40358, 2024. 
Bozic, K. J., Lau, E., Kurtz, S., Ong, K., and Berry, D. J.: Patient-related risk factors for postoperative mortality and periprosthetic joint infection in medicare patients undergoing TKA, Clin. Orthop. Relat. Res., 470, 130–137, https://doi.org/10.1007/s11999-011-2043-3, 2012. 
Chesnaye, N. C., Stel, V. S., Tripepi, G., Dekker, F. W., Fu, E. L., Zoccali, C., and Jager, K. J.: An introduction to inverse probability of treatment weighting in observational research, Clin. Kidney J., 15, 14–20, https://doi.org/10.1093/ckj/sfab158, 2022. 
Drain, N. P., Bertolini, D. M., Anthony, A. W., Feroze, M. W., Chao, R., Onyekweli, T., Longo, S. E., Hersh, B. L., Smith, C. N., Rothenberger, S. D., Shah, N. B., and Urish, K. L.: High Mortality After Total Knee Arthroplasty Periprosthetic Joint Infection is Related to Preoperative Morbidity and the Disease Process but Not Treatment, J. Arthroplasty, 37, 1383–1389, https://doi.org/10.1016/j.arth.2022.03.046, 2022. 
Gubbels, S.: Healthcare-Associated Infections Database, HAIBA, PhD thesis, Statens Serum Institut, Copenhagen University, Denmark, https://miba.ssi.dk/-/media/arkiv/subsites/miba-og-haiba/dokument/sophie-gubbels_phd.pdf?la=da (last access: 3 December 2025), 2016. 
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Short summary
Patients who undergo repeat surgery due to joint infection after a hip or knee replacement have a higher risk of dying compared with those who have revision surgery for other reasons. We studied more than 9000 patients using national health data to explore why this happens. We found that the higher risk cannot be explained by a single cause of death but is linked to many common health problems. This suggests that these patients are especially vulnerable and may need broader medical support.
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