Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 2
Articles | Volume 10, issue 2
https://doi.org/10.5194/jbji-10-51-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-51-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 2
Original full-length article
 | 
07 Mar 2025
Original full-length article |  | 07 Mar 2025

Postoperative antibiotic treatment does not lower re-revision rate in presumed aseptic hip and knee revision arthroplasties with unexpected positive intraoperative cultures – a matched cohort study

Sebastian Simon, Marjan Wouthuyzen-Bakker, Susana Gardete Hartmann, Jennyfer A. Mitterer, Sujeesh Sebastian, Stephanie Huber, Bernhard J. H. Frank, and Jochen G. Hofstaetter

Related authors

Risk factors for treatment failure in late acute periprosthetic joint infection in patients with rheumatoid arthritis treated with surgical debridement – a case-control study
Hendrika M. Schenk, Marine Sebillotte, Jose Lomas, Adrian Taylor, Eva Benavent, Oscar Murillo, Marta Fernandez-Sampedro, Kaisa Huotari, Craig Aboltins, Rihard Trebse, Alex Soriano, Marjan Wouthuyzen-Bakker, and on behalf of the ESCMID Study Group on Implant Associated Infections (ESGIAI)
J. Bone Joint Infect., 10, 217–224, https://doi.org/10.5194/jbji-10-217-2025,https://doi.org/10.5194/jbji-10-217-2025, 2025
Short summary
Debridement, antimicrobial therapy, and implant retention (DAIR) as curative surgical strategy for acute periprosthetic hip and knee infections: a summary of the position paper from the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Marjan Wouthuyzen-Bakker, Tristan Ferry, Willem-Jan Metsemakers, Martin Clauss, Alex Soriano, Rihard Trebse, and Ricardo Sousa
J. Bone Joint Infect., 10, 139–142, https://doi.org/10.5194/jbji-10-139-2025,https://doi.org/10.5194/jbji-10-139-2025, 2025
Short summary
Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)
Irene K. Sigmund, Tristan Ferry, Ricardo Sousa, Alex Soriano, Willem-Jan Metsemakers, Martin Clauss, Rihard Trebse, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 10, 101–138, https://doi.org/10.5194/jbji-10-101-2025,https://doi.org/10.5194/jbji-10-101-2025, 2025
Short summary
Predicting periprosthetic joint infection: external validation of preoperative prediction models
Seung-Jae Yoon, Paul C. Jutte, Alex Soriano, Ricardo Sousa, Wierd P. Zijlstra, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 9, 231–239, https://doi.org/10.5194/jbji-9-231-2024,https://doi.org/10.5194/jbji-9-231-2024, 2024
Short summary
Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E. Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T. Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Kraševac Glaser, Juha O. Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J. Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S. P. Moore, Lynn Moffat, Marianna Murdjeva, Michael E. Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, and Florence Allantaz
J. Bone Joint Infect., 9, 87–97, https://doi.org/10.5194/jbji-9-87-2024,https://doi.org/10.5194/jbji-9-87-2024, 2024
Short summary
More articles (5)

Related subject area

Subject: Treatment outcome analysis | Topic: All topics
One- versus two-stage septic hip and knee revision surgery: a comparative cohort outcome study with short- to mid-term follow-up
Michelle M. J. Jacobs, Petra J. C. Heesterbeek, Karin Veerman, and Jon H. M. Goosen
J. Bone Joint Infect., 10, 185–192, https://doi.org/10.5194/jbji-10-185-2025,https://doi.org/10.5194/jbji-10-185-2025, 2025
Short summary
Optimal antibiotics duration following surgical management of septic olecranon bursitis: a 12-year retrospective analysis
Said El Zein, Elie F. Berbari, Allison M. LeMahieu, Anil Jagtiani, Parham Sendi, Abinash Virk, Mark E. Morrey, and Aaron J. Tande
J. Bone Joint Infect., 9, 107–115, https://doi.org/10.5194/jbji-9-107-2024,https://doi.org/10.5194/jbji-9-107-2024, 2024
Short summary
A desirability of outcome ranking (DOOR) for periprosthetic joint infection – a Delphi analysis
Brenton P. Johns, David C. Dewar, Mark R. Loewenthal, Laurens A. Manning, Amit Atrey, Nipun Atri, David G. Campbell, Michael Dunbar, Christopher Kandel, Amir Khoshbin, Christopher W. Jones, Jaime Lora-Tamayo, Catherine McDougall, Dirk Jan F. Moojen, Jonathan Mulford, David L. Paterson, Trisha Peel, Michael Solomon, Simon W. Young, and Joshua S. Davis
J. Bone Joint Infect., 7, 221–229, https://doi.org/10.5194/jbji-7-221-2022,https://doi.org/10.5194/jbji-7-221-2022, 2022
Short summary
Higher 1-year risk of implant removal for culture-positive than for culture-negative DAIR patients following 359 primary hip or knee arthroplasties
Joyce van Eck, Wai-Yan Liu, Jon H. M. Goosen, Wim H. C. Rijnen, Babette C. van der Zwaard, Petra Heesterbeek, Walter van der Weegen, and the further members of Regional Prosthetic Joint Infection Group
J. Bone Joint Infect., 7, 143–149, https://doi.org/10.5194/jbji-7-143-2022,https://doi.org/10.5194/jbji-7-143-2022, 2022
Short summary
A retrospective cohort study comparing clinical outcomes and healthcare resource utilisation in patients undergoing surgery for osteomyelitis in England: a case for reorganising orthopaedic infection services
Jamie Ferguson, Myriam Alexander, Stuart Bruce, Matthew O'Connell, Sue Beecroft, and Martin McNally
J. Bone Joint Infect., 6, 151–163, https://doi.org/10.5194/jbji-6-151-2021,https://doi.org/10.5194/jbji-6-151-2021, 2021
More articles (1)

Cited articles

Akgün, D., Müller, M., Perka, C., and Winkler, T.: The serum level of C-reactive protein alone cannot be used for the diagnosis of prosthetic joint infections, especially in those caused by organisms of low virulence, Bone Joint J., 100-B, 1482–1486, https://doi.org/10.1302/0301-620X.100B11.BJJ-2018-0514.R1, 2018. 
Austin, P. C.: An introduction to propensity score methods for reducing the effects of confounding in observational studies, Multivar. Behav. Res., 46, 399–424, https://doi.org/10.1080/00273171.2011.568786, 2011. 
Barrack, R. L., Aggarwal, A., Burnett, R. S. J., Clohisy, J. C., Ghanem, E., Sharkey, P., and Parvizi, J.: The Fate of the Unexpected Positive Intraoperative Cultures After Revision Total Knee Arthroplasty, J. Arthroplast., 22, 94–99, https://doi.org/10.1016/j.arth.2007.03.029, 2007. 
Di Martino, A., Bordini, B., Barile, F., Ancarani, C., Digennaro, V., and Faldini, C.: Unicompartmental knee arthroplasty has higher revisions than total knee arthroplasty at long term follow-up: a registry study on 6453 prostheses, Knee Surgery, Sport. Traumatol. Arthrosc., 29, 3323–3329, https://doi.org/10.1007/s00167-020-06184-1, 2021. 
Everhart, J. S., Andridge, R. R., Scharschmidt, T. J., Mayerson, J. L., Glassman, A. H., and Lemeshow, S.: Development and Validation of a Preoperative Surgical Site Infection Risk Score for Primary or Revision Knee and Hip Arthroplasty, J. Bone Jt. Surg., 98, 1522–1532, https://doi.org/10.2106/JBJS.15.00988, 2016. 
More articles (28)
Download
Short summary
We compared the re-revision rates in rTHA and rTKA (revison total hip and knee arthroplasty) with and without AB (antibiotic) treatment in patients with UPICs (unexpected positive intraoperative cultures). The re-revision rate between the AB group and the non-AB group was similar. Postoperative AB treatment did not result in a decreased re-revision rate in patients with UPICs in presumed aseptic rTHA and rTKA. Patients with pathogens classified as a likely contaminant can be safely ignored.

Read more
Share