Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 2
Articles | Volume 10, issue 2
https://doi.org/10.5194/jbji-10-51-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-51-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 2
Original full-length article
 | 
07 Mar 2025
Original full-length article |  | 07 Mar 2025

Postoperative antibiotic treatment does not lower re-revision rate in presumed aseptic hip and knee revision arthroplasties with unexpected positive intraoperative cultures – a matched cohort study

Sebastian Simon, Marjan Wouthuyzen-Bakker, Susana Gardete Hartmann, Jennyfer A. Mitterer, Sujeesh Sebastian, Stephanie Huber, Bernhard J. H. Frank, and Jochen G. Hofstaetter

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Cited articles

Akgün, D., Müller, M., Perka, C., and Winkler, T.: The serum level of C-reactive protein alone cannot be used for the diagnosis of prosthetic joint infections, especially in those caused by organisms of low virulence, Bone Joint J., 100-B, 1482–1486, https://doi.org/10.1302/0301-620X.100B11.BJJ-2018-0514.R1, 2018. 
Austin, P. C.: An introduction to propensity score methods for reducing the effects of confounding in observational studies, Multivar. Behav. Res., 46, 399–424, https://doi.org/10.1080/00273171.2011.568786, 2011. 
Barrack, R. L., Aggarwal, A., Burnett, R. S. J., Clohisy, J. C., Ghanem, E., Sharkey, P., and Parvizi, J.: The Fate of the Unexpected Positive Intraoperative Cultures After Revision Total Knee Arthroplasty, J. Arthroplast., 22, 94–99, https://doi.org/10.1016/j.arth.2007.03.029, 2007. 
Di Martino, A., Bordini, B., Barile, F., Ancarani, C., Digennaro, V., and Faldini, C.: Unicompartmental knee arthroplasty has higher revisions than total knee arthroplasty at long term follow-up: a registry study on 6453 prostheses, Knee Surgery, Sport. Traumatol. Arthrosc., 29, 3323–3329, https://doi.org/10.1007/s00167-020-06184-1, 2021. 
Everhart, J. S., Andridge, R. R., Scharschmidt, T. J., Mayerson, J. L., Glassman, A. H., and Lemeshow, S.: Development and Validation of a Preoperative Surgical Site Infection Risk Score for Primary or Revision Knee and Hip Arthroplasty, J. Bone Jt. Surg., 98, 1522–1532, https://doi.org/10.2106/JBJS.15.00988, 2016. 
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We compared the re-revision rates in rTHA and rTKA (revison total hip and knee arthroplasty) with and without AB (antibiotic) treatment in patients with UPICs (unexpected positive intraoperative cultures). The re-revision rate between the AB group and the non-AB group was similar. Postoperative AB treatment did not result in a decreased re-revision rate in patients with UPICs in presumed aseptic rTHA and rTKA. Patients with pathogens classified as a likely contaminant can be safely ignored.

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