Articles | Volume 10, issue 6
https://doi.org/10.5194/jbji-10-479-2025
https://doi.org/10.5194/jbji-10-479-2025
Original full-length article
 | 
25 Nov 2025
Original full-length article |  | 25 Nov 2025

Modular megaprostheses yield high any-type failure rate but acceptable infection control rate in patients with chronic hip and knee periprosthetic joint infection and severe bone loss: a single-center experience

Vladislav Bartak, David Jahoda, Michal Benes, Tobias Judl, Matej Mazura, and Petr Fulin

Cited articles

Alvand, A., Grammatopoulos, G., de Vos, F., Scarborough, M., Kendrick, B., Price, A., Gundle, R., Whitwell, D., Jackson, W., Taylor, A., and Gibbons, C. L. M. H.: Clinical outcome of massive endoprostheses used for managing periprosthetic joint infections of the hip and knee, J. Arthroplasty, 33, 829–834, https://doi.org/10.1016/j.arth.2017.09.046, 2018. 
Artiaco, S., Boggio, F., Colzani, G., Titolo, P., Zoccola, K., Bianchi, P., and Bellomo, F.: Megaprostheses in the revision of infected total hip arthroplasty: clinical series and literature review, Bull. Hosp. Jt. Dis., 73, 229–232, 2013. 
Bourget-Murray, J., Azad, M., Gofton, W., Abdelbary, H., Garceau, S., and Grammatopoulos, G.: Is the routine use of local antibiotics in the management of periprosthetic joint infections justified?, Hip Int., 7, 11–21, 2022. 
Corona, P. S., Vicente, M., Lalanza, M., Amat, C., and Carrera, L.: Use of modular megaprosthesis in managing chronic end-stage periprosthetic hip and knee infections: Is there an increase in relapse rate?, Eur. J. Orthop. Surg. Traumatol., 28, 627–636, https://doi.org/10.1007/s00590-018-2127-9, 2018. 
Crimi, A., Joyce, D. M., Binite, O., Ruggieri, P., and Letson, G. D.: The history of resection prosthesis, Int. Orthop., 47, 873–883, https://doi.org/10.1007/s00264-023-05698-w, 2023. 
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Short summary
This single-center retrospective study focused on the utility of modular megaprostheses in patients with chronic hip or knee periprosthetic joint infections. Among the 61 included patients, 37.7 % experienced any type of failure, with infection recurrence being the most common reason. While infection control was acceptable, the rates of any-type failure were high. Moreover, patients classified as McPherson host grade C, representing compromised hosts, are at greater risk of experiencing failure.
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