Articles | Volume 10, issue 5
https://doi.org/10.5194/jbji-10-337-2025
https://doi.org/10.5194/jbji-10-337-2025
Original full-length article
 | 
08 Sep 2025
Original full-length article |  | 08 Sep 2025

Prevalence, microbiological features, and risk factors for periprosthetic joint infections in oncologic patients following tumor resection and megaprosthetic reconstruction

Andreas G. Tsantes, Dimitrios V. Papadopoulos, Stavros Goumenos, Eleni Petrou, Ioannis G. Trikoupis, Anastasios Roustemis, Alexandra Mpakosi, Petros Ioannou, Christos Koutserimpas, Panayiotis Gavriil, Daniele Piovani, Stefanos Bonovas, Panayiotis J. Papagelopoulos, Athanasios Tsakris, and Argirios E. Tsantes

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Cited articles

Ahmad, M. A., Ab Rahman, S., and Islam, M. A.: Prevalence and Risk of Infection in Patients with Diabetes following Primary Total Knee Arthroplasty: A Global Systematic Review and Meta-Analysis of 120,754 Knees, J. Clin. Med., 11, 3752, https://doi.org/10.3390/jcm11133752, 2022. 
Anatone, A. J., Danford, N. C., Jang, E. S., Smartt, A., Konigsberg, M., and Tyler, W. K.: Risk Factors for Surgical Site Infection in Orthopaedic Oncology, J. Am. Acad. Orthop. Sur., 28, e923–e928, https://doi.org/10.5435/JAAOS-D-19-00582, 2020. 
Bauer, T. W., Bedair, H., Creech, J. D., Deirmengian, C., Eriksson, H., Fillingham, Y., Grigoryan, G., Hickok, N., Krenn, V., Krenn, V., Lazarinis, S., Lidgren, L., Lonner, J., Odum, S., Shah, J., Shahi, A., Shohat, N., Tarabichi, M., W-Dahl, A., and Wongworawat, M. D.: Hip and Knee Section, Diagnosis, Laboratory Tests: Proceedings of International Consensus on Orthopedic Infections, J. Arthroplast., 34, S351–S359, https://doi.org/10.1016/j.arth.2018.09.019, 2019. 
Bozic, K. J., Ward, D. T., Lau, E. C., Chan, V., Wetters, N. G., Naziri, Q., Odum, S., Fehring, T. K., Mont, M. A., Gioe, T. J., and Della Valle, C. J.: Risk factors for periprosthetic joint infection following primary total hip arthroplasty: a case control study, J. Arthroplast., 29, 154–156, https://doi.org/10.1016/j.arth.2013.04.015, 2014. 
Cheng, H., Chen, B. P., Soleas, I. M., Ferko, N. C., Cameron, C. G., and Hinoul, P.: Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review, Surg. Infect., 18, 722–735, https://doi.org/10.1089/sur.2017.089, 2017. 
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Short summary
Our results indicate that certain parameters such as diabetes, low albumin levels, and prolonged duration of surgery are associated with a higher risk of infection in patients undergoing musculoskeletal tumor resection and megaprosthetic reconstruction. Strategies targeted towards glycemic control and nutritional status optimization are of great significance, while parameters that can affect the operating time can also have a positive impact on periprosthetic joint infection prevention.
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