Articles | Volume 10, issue 5
https://doi.org/10.5194/jbji-10-337-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-337-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Prevalence, microbiological features, and risk factors for periprosthetic joint infections in oncologic patients following tumor resection and megaprosthetic reconstruction
Andreas G. Tsantes
CORRESPONDING AUTHOR
Laboratory of Haematology and Blood Bank Unit, “Attiko” Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Microbiology Department, “Saint Savvas” Oncology Hospital, 11522 Athens, Greece
Dimitrios V. Papadopoulos
Second Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Stavros Goumenos
First Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany
Eleni Petrou
Laboratory of Haematology and Blood Bank Unit, “Attiko” Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Ioannis G. Trikoupis
First Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
The Royal Orthopedic Hospital, NHS Foundation Trust, Birmingham, UK
Anastasios Roustemis
First Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Alexandra Mpakosi
Department of Microbiology, General Hospital of Nikaia “Agios Panteleimon”, 18454 Piraeus, Greece
Petros Ioannou
Department of Internal Medicine & Infectious Diseases, University General Hospital of Heraklion, Heraklion, Greece
Christos Koutserimpas
Orthopaedics Surgery and Sports Medicine Department, FIFA Medical Center of Excellence, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon North University Hospital, Lyon, France
Panayiotis Gavriil
First Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Daniele Piovani
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Stefanos Bonovas
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
Panayiotis J. Papagelopoulos
First Department of Orthopaedics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Athanasios Tsakris
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Argirios E. Tsantes
Laboratory of Haematology and Blood Bank Unit, “Attiko” Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Pia Reinecke, Svetlana Karbysheva, Stavros Goumenos, Anna Conen, Olga Pidgaiska, Carsten Perka, Andrej Trampuz, Thilo Khakzad, and Sebastian Meller
J. Bone Joint Infect., 11, 267–275, https://doi.org/10.5194/jbji-11-267-2026, https://doi.org/10.5194/jbji-11-267-2026, 2026
Short summary
Short summary
This study examined how people with difficult joint infections manage long-term antibiotic treatment when the infection cannot be fully removed. We followed patients to record side effects and overall well-being. Many had stomach or skin problems, but most continued treatment. The results show that attentive follow-up and personalised care keep this therapy manageable and may guide better support in practice.
Efthymia Giannitsioti, Mauro José Salles, Andreas Mavrogenis, Dolors Rodriguez-Pardo, Ibai Los-Arcos, Alba Ribera, Javier Ariza, María Dolores del Toro, Sophie Nguyen, Eric Senneville, Eric Bonnet, Monica Chan, Maria Bruna Pasticci, Sabine Petersdorf, Natividad Benito, Nuala O' Connell, Antonio Blanco García, Gábor Skaliczki, Pierre Tattevin, Zeliha Kocak Tufan, Nikolaos Pantazis, Panayiotis D. Megaloikonomos, Panayiotis Papagelopoulos, Alejandro Soriano, Antonios Papadopoulos, and the ESGIAI collaborators study group
J. Bone Joint Infect., 7, 279–288, https://doi.org/10.5194/jbji-7-279-2022, https://doi.org/10.5194/jbji-7-279-2022, 2022
Short summary
Short summary
Our multicentre study on a lower-limb osteosynthesis-associated infection (OAI) cohort by multidrug (MDR) and extensively drug (XDR) resistant Gram-negative bacteria found the following: implant retention with debridement was mostly performed in early OAI; 50.9 % of patients achieved remission of infection; remission reached 50 % (MDR) vs. 25 % (XDR) in early OAI and 60 % (MDR) vs. 44.4 % (XDR) in late OAI; age (> 60) and multiple surgeries were independent factors influencing lack of remission.
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Short summary
Our results indicate that certain parameters such as diabetes, low albumin levels, and prolonged duration of surgery are associated with a higher risk of infection in patients undergoing musculoskeletal tumor resection and megaprosthetic reconstruction. Strategies targeted towards glycemic control and nutritional status optimization are of great significance, while parameters that can affect the operating time can also have a positive impact on periprosthetic joint infection prevention.
Our results indicate that certain parameters such as diabetes, low albumin levels, and prolonged...