Articles | Volume 10, issue 1
https://doi.org/10.5194/jbji-10-33-2025
https://doi.org/10.5194/jbji-10-33-2025
Original full-length article
 | 
26 Feb 2025
Original full-length article |  | 26 Feb 2025

Rethinking antibiotic prophylaxis in orthopaedic oncology: insights from a cohort study of endoprosthetic infections

Tariq Azamgarhi, Craig Gerrand, and Simon Warren

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Cited articles

Ghert, M., Schneider, P., Guyatt, G., Thabane, L., Vélez, R., O'Shea, T., Randall, R. L., Turcotte, R., Wilson, D., Wunder, J. S., Baptista, A. M., Cheng, E. Y., Doung, Y. C., Ferguson, P. C., Giglio, V., Hayden, J., Heels-Ansdell, D., Khan, S. A., Sampath Kumar, V., McKay, P., Miller, B., Van De Sande, M., Zumárraga, J. P., and Bhandari, M.: Comparison of Prophylactic Intravenous Antibiotic Regimens after Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial, JAMA Oncol., 8, 345–353, https://doi.org/10.1001/jamaoncol.2021.6628, 2022. 
Harrington, P., Wloch, C., Elgohari, S., and Lamagni, T.: Protocol for the surveillance of surgical site infection. Surgical Site Infection Surveillance Service, Public Heath England, London, 2013. 
Jeys, L. M., Grimer, R. J., Carter, S. R., and Tillman, R. M.: Periprosthetic Infection in Patients Treated for an Orthopaedic Oncological Condition, J. Bone Joint Surg., 87, 842–849, https://doi.org/10.2106/JBJS.C.01222, 2005. 
McNally, M., Sigmund, I., Hotchen, A., and Sousa, R.: Making the diagnosis in prosthetic joint infection: a European view, EFORT Open Rev,, 8, 253–263, https://doi.org/10.1530/EOR-23-0044, 2023. 
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Short summary
We explore optimising antibiotic use to prevent infections in endoprosthetic replacement for bone tumours. We found 26 % of infections were linked to initial surgery, with most due to secondary factors like wound complications. The main bacteria are Staphylococcus aureus and coagulase-negative staphylococci. Our findings suggest targeting these bacteria with prophylactic antibiotics and applying measures to prevent secondary infections to improve infection control in orthopaedic oncology.
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