Articles | Volume 10, issue 4
https://doi.org/10.5194/jbji-10-293-2025
https://doi.org/10.5194/jbji-10-293-2025
Original full-length article
 | 
13 Aug 2025
Original full-length article |  | 13 Aug 2025

Synovial pH, lactate, and glucose as adjunct biomarkers to exclude periprosthetic joint infection in hip and knee arthroplasty: a prospective study

Dirk Müller, Joshua Aulenbacher, Niels Heine, Benjamin Schloßmacher, Vincent Lallinger, Georg Matziolis, Rüdiger von Eisenhart-Rothe, and Igor Lazic

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External validation of the joint-specific bone involvement, antimicrobial options, coverage of the soft tissues, and host status (JS-BACH) classification for predicting the outcome in periprosthetic joint infections following total hip and knee arthroplasties: a promising tool for clinical practice
Benjamin Schlossmacher, Vincent Lallinger, Dirk Müller, Rüdiger von Eisenhart-Rothe, and Igor Lazic
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Cited articles

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Short summary
Synovial fluid pH, lactate, and glucose levels have been studied in native joint septic arthritis, but their diagnostic value in periprosthetic joint infection (PJI) remains insufficiently explored. This prospective study of 100 patients assessed their utility for PJI diagnosis. PJI cases showed significantly lower synovial pH and glucose levels but higher lactate levels. The combined analysis of all three biomarkers yielded a negative predictive value of 84 % for PJI diagnosis.
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