Articles | Volume 10, issue 4
https://doi.org/10.5194/jbji-10-293-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-293-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Synovial pH, lactate, and glucose as adjunct biomarkers to exclude periprosthetic joint infection in hip and knee arthroplasty: a prospective study
Dirk Müller
CORRESPONDING AUTHOR
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Joshua Aulenbacher
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Niels Heine
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Benjamin Schloßmacher
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Vincent Lallinger
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Georg Matziolis
Orthopaedic Department, Friedrich-Schiller-University Jena, University Hospital Jena, Campus Eisenberg, Klosterlausnitzer Str. 81, 07607 Eisenberg, Germany
Rüdiger von Eisenhart-Rothe
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Igor Lazic
Department of Orthopaedic Surgery, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany
Related authors
Benjamin Schlossmacher, Vincent Lallinger, Dirk Müller, Rüdiger von Eisenhart-Rothe, and Igor Lazic
J. Bone Joint Infect., 10, 501–509, https://doi.org/10.5194/jbji-10-501-2025, https://doi.org/10.5194/jbji-10-501-2025, 2025
Short summary
Short summary
This study performed an external validation of the so-called JS-BACH classification from 2021, which aims to help predict the outcome of periprosthetic joint infections using three groups of increasing severity. Using data from 249 patients, we found that higher severity scores were strongly linked to an increased failure rate. This simple tool could guide doctors in tailoring treatments and improving results for patients with these challenging infections.
Benjamin Schlossmacher, Vincent Lallinger, Dirk Müller, Rüdiger von Eisenhart-Rothe, and Igor Lazic
J. Bone Joint Infect., 10, 501–509, https://doi.org/10.5194/jbji-10-501-2025, https://doi.org/10.5194/jbji-10-501-2025, 2025
Short summary
Short summary
This study performed an external validation of the so-called JS-BACH classification from 2021, which aims to help predict the outcome of periprosthetic joint infections using three groups of increasing severity. Using data from 249 patients, we found that higher severity scores were strongly linked to an increased failure rate. This simple tool could guide doctors in tailoring treatments and improving results for patients with these challenging infections.
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Short summary
Synovial fluid pH, lactate, and glucose levels have been studied in native joint septic arthritis, but their diagnostic value in periprosthetic joint infection (PJI) remains insufficiently explored. This prospective study of 100 patients assessed their utility for PJI diagnosis. PJI cases showed significantly lower synovial pH and glucose levels but higher lactate levels. The combined analysis of all three biomarkers yielded a negative predictive value of 84 % for PJI diagnosis.
Synovial fluid pH, lactate, and glucose levels have been studied in native joint septic...