Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 4
Articles | Volume 10, issue 4
https://doi.org/10.5194/jbji-10-293-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-293-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 4
Original full-length article
 | 
13 Aug 2025
Original full-length article |  | 13 Aug 2025

Synovial pH, lactate, and glucose as adjunct biomarkers to exclude periprosthetic joint infection in hip and knee arthroplasty: a prospective study

Dirk Müller, Joshua Aulenbacher, Niels Heine, Benjamin Schloßmacher, Vincent Lallinger, Georg Matziolis, Rüdiger von Eisenhart-Rothe, and Igor Lazic

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Short summary
Synovial fluid pH, lactate, and glucose levels have been studied in native joint septic arthritis, but their diagnostic value in periprosthetic joint infection (PJI) remains insufficiently explored. This prospective study of 100 patients assessed their utility for PJI diagnosis. PJI cases showed significantly lower synovial pH and glucose levels but higher lactate levels. The combined analysis of all three biomarkers yielded a negative predictive value of 84 % for PJI diagnosis.
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