Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 10, issue 3
Articles | Volume 10, issue 3
https://doi.org/10.5194/jbji-10-199-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-10-199-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 10, issue 3
Original full-length article
 | 
16 Jun 2025
Original full-length article |  | 16 Jun 2025

CLOSE-UP – a favourable protocol for limb-sparing surgery of diabetic foot osteomyelitis

Anton Alexander Nolte Peterlin, Louise Kruse Jensen, Emil Gleipner-Andersen, and Hans Gottlieb

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Latest update: 03 Oct 2026
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Short summary
Diabetic foot osteomyelitis is a severe diabetes complication that increases the risk of limb loss and death. This study assessed a one-stage surgical approach with primary wound closure and local antibiotics, showing favourable results. Among 97 patients, 13 needed further treatment, but only 4 required major amputation. Poor circulation was the main factor in failure. These findings challenge traditional methods and may improve quality of life, although further high-quality trials are needed.
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