Articles | Volume 10, issue 2
https://doi.org/10.5194/jbji-10-143-2025
https://doi.org/10.5194/jbji-10-143-2025
Review
 | 
08 Apr 2025
Review |  | 08 Apr 2025

Oral tetracyclines for bone and joint infections: what do we know?

Tom Cartau, Jocelyn Michon, Renaud Verdon, and Aurelie Baldolli

Related subject area

Subject: Prosthesis-related infections | Topic: Antibiotic therapy
Effect of oral antibiotics after two-stage revision for periprosthetic joint infection on subsequent antibiotic resistance within a national cohort of United States veterans
Judd Payne, Jesse D. Sutton, Brenna E. Blackburn, Snehal Bansod, Hannah Imlay, Emily S. Spivak, Jakrapun Pupaibool, Jeremy M. Gililland, and Laura K. Certain
J. Bone Joint Infect., 10, 7–14, https://doi.org/10.5194/jbji-10-7-2025,https://doi.org/10.5194/jbji-10-7-2025, 2025
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J. Bone Joint Infect., 9, 149–159, https://doi.org/10.5194/jbji-9-149-2024,https://doi.org/10.5194/jbji-9-149-2024, 2024
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No differences in outcomes with stopping or continuing antibiotic suppression in periprosthetic joint infections
Daisuke Furukawa, Megan Dunning, Sa Shen, Amy Chang, Jenny Aronson, Derek F. Amanatullah, Gina A. Suh, and Shanthi Kappagoda
J. Bone Joint Infect., 9, 143–148, https://doi.org/10.5194/jbji-9-143-2024,https://doi.org/10.5194/jbji-9-143-2024, 2024
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Antibiotic prophylaxis before tissue biopsy has no effect on culture results in presumed aseptic revision total hip arthroplasty
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Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis
Nour Bouji, Sijin Wen, and Matthew J. Dietz
J. Bone Joint Infect., 7, 191–202, https://doi.org/10.5194/jbji-7-191-2022,https://doi.org/10.5194/jbji-7-191-2022, 2022
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Cited articles

Agwuh, K. N. and MacGowan, A.: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines, J. Antimicrob. Chemoth., 58, 256–265, https://doi.org/10.1093/jac/dkl224, 2006. 
Ariza, J., Cobo, J., Baraia-Etxaburu, J., Benito, N., Bori, G., Cabo, J., Corona, P., Esteban, J., Horcajada, J. P., Lora-Tamayo, J., Murillo, O., Palomino, J., Parra, J., Pigrau, C., Del Pozo, J. L., Riera, M., Rodríguez, D., Sánchez-Somolinos, M., Soriano, A., Del Toro, M. D., and De La Torre, B.: Executive summary of management of prosthetic joint infections. Clinical practice guidelines by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), Enferm. Infec. Micr. Cl., 35, 189–195, https://doi.org/10.1016/j.eimc.2016.08.012, 2017. 
Astagneau, P.: Rapport national de la surveillance semi-automatisée des infections du site opératoire en chirurgie – Données 2020 et 2021, https://www.cpias-ile-de-france.fr/spicmi/surveillance/Rapport_2020_2021_Spicmi.pdf (last access: 3 April 2025), 2023. 
Bahrami, F., Morris, D. L., and Pourgholami, M. H.: Tetracyclines: drugs with huge therapeutic potential, Mini-Rev. Med. Chem., 12, 44–52, https://doi.org/10.2174/138955712798868977, 2012. 
Bart, G., Zeller, V., Kerroumi, Y., Heym, B., Meyssonnier, V., Desplaces, N., Kitzis, M. D., Ziza, J. M., and Marmor, S.: Minocycline Combined with Vancomycin for the Treatment of Methicillin-Resistant Coagulase-Negative Staphylococcal Prosthetic Joint Infection Managed with Exchange Arthroplasty, J. Bone Joint Infect., 5, 110–117, https://doi.org/10.7150/jbji.43254, 2020. 
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Short summary
Bone and joint infections are common and generally require surgical treatment combined with prolonged antibiotic therapy. It is important to use an antibiotic with good bone penetration that is effective against the commonly encountered pathogens and well-tolerated. Oral tetracyclines are promising and frequently used candidates. This review summarizes the available data on the use of oral tetracyclines in bone and joint infections and highlights the limited data available.
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