Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Romanò, Carlo Luca; Malizos, Kostantinos; Capuano, Nicola; Mezzoprete, Riccardo; D'Arienzo, Michele; Der, Catherine Van; Scarponi, Sara; Drago, Lorenzo

doi:https://doi.org/10.7150/jbji.15986

Articles | Volume 1, issue 1

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Articles | Volume 1, issue 1

https://doi.org/10.7150/jbji.15986

Articles | Volume 1, issue 1

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Metrics
Related articles

Original full-length article

19 Jul 2016

Original full-length article |

| 19 Jul 2016

Does an Antibiotic-Loaded Hydrogel Coating Reduce Early Post-Surgical Infection After Joint Arthroplasty?

Carlo Luca Romanò, Kostantinos Malizos, Nicola Capuano, Riccardo Mezzoprete, Michele D'Arienzo, Catherine Van Der, Sara Scarponi, and Lorenzo Drago

Carlo Luca Romanò

Department of Reconstructive Surgery of Osteo-articular Infections C.R.I.O. Unit, I.R.C.C.S. Galeazzi Orthopaedic Institute, Milano, Italy.

Kostantinos Malizos

Orthopaedic Surgery & Trauma, Medical School, University of Thessaly, Larissa, Greece.

Nicola Capuano

Department of Orthopaedics, San Luca Hospital - Vallo della Lucania, Italy.

Riccardo Mezzoprete

Department of Orthopaedics, San Camillo de Lellis Hospital - Rieti, Italy.

Michele D'Arienzo

Orthopaedic Surgery & Trauma, University Clinic, Palermo, Italy.

Catherine Van Der

Department of Orthopaedics, Medical University Ghent, Belgium.

MSK Lab, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Sara Scarponi

Department of Reconstructive Surgery of Osteo-articular Infections C.R.I.O. Unit, I.R.C.C.S. Galeazzi Orthopaedic Institute, Milano, Italy.

Lorenzo Drago

Clinical Chemistry and Microbiology Laboratory, I.R.C.C.S. Galeazzi Orthopaedic Institute, Milano, Italy.

Laboratory of Medical Technical Sciences, Department of Biochemical Sciences for Health, University of Milano, Italy.

Cited articles

Magill S.S. et al. Multistate point-prevalence survey of health care-associated infections. New England J of Medicine. 2014;370(13):1198–1208. [PMC free article]

An Y.H., Friedman R.J. Prevention of sepsis in total joint arthroplasty. J Hosp Infect. 1996;33:93–108.

Humphreys H. Surgical site infection, ultraclean ventilated operating theatres and prosthetic joint surgery: Where now? J Hosp Infect. 2012;81:71–72.

Jamsen E, Furnes O, Engesaeter LB, Konttinen YT, Odgaard A, Stefansdottir A. et al. Prevention of deep infection in joint replacement surgery. Acta Orthop. 2010;81:660e6. [PMC free article]

Illingworth K.D. et al. How to minimize infection and thereby maximize patient outcomes in total joint arthroplasty: a multicenter approach: AAOS exhibit selection. J Bone J Surg Am. 2013;95:e50.

Magill S.S. et al. Prevalence of healthcare-associated infections in acute care hospitals in Jacksonville, Florida. Infection Control Hospital Epidemiology. 2012;33(3):283–91. [PMC free article]

Lentino J.R. Prosthetic joint infections: Bane of orthopedists, challenge for infectious disease specialists. Clin. Infect. Dis. 2003;36:1157–1161.

Illingworth K.D. et al. How to minimize infection and thereby maximize patient outcomes in total joint arthroplasty: a multicenter approach: AAOS exhibit selection. J. Bone Jt. Surg. Am. 2013;95:e50.

Pruzansky JS, Bronson MJ, Grelsamer RP, Strauss E, Moucha CS. Prevalence of modifiable surgical site infection risk factors in hip and knee joint arthroplasty patients at an urban academic hospital. J. Arthroplast. 2014;29:272–276.

Berbari EF, Osmon DR, Lahr B, Eckel-Passow JE, Tsaras G, Hanssen AD, Mabry T, Steckelberg J, Thompson R. The Mayo prosthetic joint infection risk score: Implication for surgical site infection reporting and risk stratification. Infect. Control Hosp. Epidemiol. 2012;33:774–781.

Aggarwal V.K. et al. Mitigation and education. J. Arthroplast. 2014;29:19–25.

Dale H., Hallan G., Hallan G., Espehaug B., Havelin L.I., Engesaeter L.B. Increasing risk of revision due to deep infection after hip arthroplasty. Acta Orthop. 2009;80:639–645. [PMC free article]

Aggarwal VK, Bakhshi H, Ecker NU, Parvizi J, Gehrke T, Kendoff D. Organism profile in periprosthetic joint infection: Pathogens differ at two arthroplasty infection referral centers in Europe and in the United States. J Knee Surg; 2014. p. 10. doi:10.1055/s-0033-1364102.

Zmistowski B, Karam JA, Durinka JB, Casper DS, Parvizi J. Periprosthetic joint infection increases the risk of one-year mortality. J. Bone Jt. Surg. Am. 2013;95:2177–2184.

Kurtz SM, Lau E Watson H, Schmier JK Parvizi J. Economic burden of periprosthetic joint infection in the United States. J. Arthroplast. 2012;27:61–65.

Poultsides LA, Liaropoulos LL, Malizos KN. The socioeconomic impact of musculoskeletal infections. J Bone Joint Surg Am. 2010;92:e13.

Goodman SB, Yao Z, Keeney M, Yang F. The future of biologic coatings for orthopaedic implants. Biomaterials. 2013;34(13):3174–3183. [PMC free article]

Cats-Baril W, Gehrke T, Huff K, Kendoff D, Maltenfort M, Parvizi J. International consensus on periprosthetic joint infection: Description of the consensus process. Clin. Orthop. Relat. Res. 2013;471:4065–4075. [PMC free article]

Romanò CL, Scarponi S, Gallazzi E, Romanò D, Drago L. Antibacterial coating of implants in orthopaedics and trauma: a classification proposal in an evolving panorama. J Orthop Surg Res. 2015;10:157. [PMC free article]

Romanò CL, Logoluso N, Drago L. Peri-Operative Medical Management for Total Joint Arthroplasty. Springer; 2014. Antibiofilm strategies in orthopedics: where are we? pp. 269–286. [Google Scholar]

Overstreet D, McLaren A, Calara F, Vernon B, McLemore R. Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective. Clin Orthop Relat Res. 2015 Jan;473(1):337–47. [PMC free article]

Pitarresi G, Palumbo FS, Calascibetta F, Fiorica C, Di Stefano M, Giammona G. Medicated hydrogels of hyaluronic acid derivatives for use in orthopedic field. Int J Pharm. 2013 Jun 5;449(1-2):84–94.

Holá V, Růžička F, Votava M. The dynamics of staphylococcus epidermis biofilm formation in relation to nutrition, temperature, and time. Scripta Medica. 2006;79:169–174. [Google Scholar]

Heydemann JS, Nelson CL. Short-term preventive antibiotics. Clin Orthop Relat Res. 1986 Apr;(205):184–7.

Antoci Jr V, Adams CS, Hickok NJ, Shapiro IM, Parvizi J. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro. Clin Orthop Relat Res. 2007;462:200–6.

Drago L, Boot W, Dimas K, Malizos K, Hänsch GM, Stuyck J, Gawlitta D, Romanò CL. Does implant coating with antibacterial-loaded hydrogel reduce bacterial colonization and biofilm formation in vitro ? Clin Orthop Relat Res. 2014 Nov;472(11):3311–23. [PMC free article]

Giavaresi G, Meani E, Sartori M, Ferrari A, Bellini D, Sacchetta AC, Meraner J, Sambri A, Vocale C, Sambri V, Fini M, Romanò CL. Efficacy of antibacterial-loaded coating in an in vivo model of acutely highly contaminated implant. Int Orthop. 2014 Jul;38(7):1505–12. [PMC free article]

Boot W, Vogely HCh, Nikkels PGJ, Pouran B, van Rijen M, Dhert WJA, Gawlitta D. Local prophylaxis of implant-related infections using a hydrogel as carrier. European Cells and Materials. 2015;30(2):19. [Google Scholar]

Malizos K, Scarponi S, Simon K, Blauth M, Romanò C. Clinical results of an anti-bacterial hydrogel coating of implants: a multi-centre, prospective, comparative study. Bone Joint J. 2015;97:138. [Google Scholar]

Slobogean GP, Kennedy SA, Davidson D, O'Brien PJ. Single- versus multiple-dose antibiotic prophylaxis in the surgical treatment of closed fractures: a meta-analysis. J Orthop Trauma. 2008 Apr;22(4):264–9.

McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis M Periprosthetic total hip infection. Outcomes using a staging system. Clin Orthop Relat Res. 2002;403:8–15.

Wilson AP, Treasure T, Sturridge MF. et al. A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet. 1986;1:311Y313.

Buchholz HW, Engelbrecht H. Depot effects of various antibiotics mixed with Palacos resins. Der Chirurg; Zeitschrift fur alle Gebiete der operative Medizen. 1970;41:511e5.

Engesaeter LB, Lie SA, Espehaug B, Furnes O, Vollset SE, Havelin LI. Antibiotic prophylaxis in total hip arthroplasty: effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register. Acta Orthop Scand. 2003;74:644e51.

Gutowski CJ, Zmistowski BM, Clyde CT, Parvizi J. The economics of using prophylactic antibiotic-loaded bone cement in total knee replacement. Bone Joint J. 2014 Jan;96(1):65–9.

Dunbar MJ. Antibiotic bone cements: their use in routine primary total joint arthroplasty is justified. Orthopedics; 2009. Sep;32(9)

van de Belt H, Neut D, Schenk W, van Horn JR, van Der Mei HC, Busscher HJ. Staphylococcus aureus biofilm formation on different gentamicin-loaded polymethylmethacrylate bone cements. Biomaterials. 2001 Jun;22(12):1607–11.

Neut D, Hendriks JG, van Horn JR, van der Mei HC, Busscher HJ. Pseudomonas aeruginosa biofilm formation and slime excretion on antibiotic-loaded bone cement. Acta Orthop. 2005 Feb;76(1):109–14.

Gallo J, Holinka M, Moucha CS. Antibacterial surface treatment for orthopaedic implants. Int J Mol Sci. 2014;15(8):13849–80. [PMC free article]

Chernousova S, Epple M. Silver as antibacterial agent: ion, nanoparticle, and metal. Angew Chem Int Ed Engl. 2013;52:1636–53.

Mijnendonckx K, Leys N, Mahillon J, Silver S, van Houdt R. Antimicrobial silver: uses, toxicity and potential for resistance. Biometals. 2013;26:609–21.

Noda I, Miyaji F, Ando Y, Miyamoto H, Shimazaki T, Yonekura Y. et al. Development of novel thermal sprayed antibacterial coating and evaluation of release properties of silver ions. J Biomed Mater Res B Appl Biomater. 2009;89:456–65.

Panacek A, Kolar M, Vecerova R, Prucek R, Soukupova J, Krystof V. et al. Antifungal activity of silver nanoparticles against Candida spp. Biomaterials. 2009;30:6333–40.

Wafa H, Grimer RJ, Reddy K, Jeys L, Abudu A, Carter SR. et al. Retrospective evaluation of the incidence of early periprosthetic infection with silver-treated endoprostheses in high-risk patients: case-control study. Bone Joint J. 2015;97:252–7.

Hardes J, von Eiff C, Streitbuerger A, Balke M, Budny T, Henrichs MP. et al. Reduction of periprosthetic infection with silver-coated megaprostheses in patients with bone sarcoma. J Surg Oncol. 2010;101(5):389–95.

Tsuchiya H, Shirai T, Nishida H, Murakami H, Kabata T, Yamamoto N. et al. Innovative antimicrobial coating of titanium implants with iodine. J Orthop Sci. 2012;17(5):595–604. [PMC free article]

Guillaume O, Garric X, Lavigne JP, Van Den Berghe H, Coudane J. Multilayer, degradable coating as a carrier for the sustained release of antibiotics: preparation and antimicrobial efficacy in vitro. J Control Release. 2012;162:492–501.

Tang Y, Zhao Y, Wang H, Gao Y, Liu X, Wang X. et al. Layer-by-layer assembly of antibacterial coating on interbonded 3D fibrous scaffolds and its cytocompatibility assessment. J Biomed Mater Res A. 2012;100:2071–8.

Neut D, Dijkstra RJ, Thompson JI, Kavanagh C, van der Mei HC, Busscher HJ. A biodegradable gentamicin-hydroxyapatite-coating for infection prophylaxis in cementless hip prostheses. Eur Cell Mater. 2015 Jan 2;29:42–55.

Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013 Jan;56(1):1–10.

Bratzler DW, Dellinger EP, Olsen KM. et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health-Syst Pharm. 2013;70:195–283.