Articles | Volume 9, issue 4
https://doi.org/10.5194/jbji-9-191-2024
https://doi.org/10.5194/jbji-9-191-2024
Brief report
 | 
24 Jul 2024
Brief report |  | 24 Jul 2024

Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection

Alexandra Wallimann, Yvonne Achermann, Ciara Ferris, Mario Morgenstern, Martin Clauss, Vincent Stadelmann, Hannes Andreas Rüdiger, Liam O'Mahony, and Thomas Fintan Moriarty

Related authors

What is the agreement between principles and practice of antibiotic stewardship in the management of diabetic foot infection: an in-hospital quality control study
Noémie Reinert, Katinka Wetzel, Fabian Franzeck, Mario Morgenstern, Markus Aschwanden, Thomas Wolff, Martin Clauss, and Parham Sendi
J. Bone Joint Infect., 9, 183–190, https://doi.org/10.5194/jbji-9-183-2024,https://doi.org/10.5194/jbji-9-183-2024, 2024
Short summary
Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E. Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T. Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Kraševac Glaser, Juha O. Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J. Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S. P. Moore, Lynn Moffat, Marianna Murdjeva, Michael E. Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, and Florence Allantaz
J. Bone Joint Infect., 9, 87–97, https://doi.org/10.5194/jbji-9-87-2024,https://doi.org/10.5194/jbji-9-87-2024, 2024
Short summary
Methylene blue for the diagnosis of a sinus tract in periprosthetic knee joint infection
Simon Martin Heinrich, Parham Sendi, and Martin Clauss
J. Bone Joint Infect., 6, 423–424, https://doi.org/10.5194/jbji-6-423-2021,https://doi.org/10.5194/jbji-6-423-2021, 2021
Short summary

Related subject area

Subject: Risk factors for bone and joint infections | Topic: All topics
Should treatment decisions in septic arthritis of the native hip joint be based on the route of infection?
Fred Ruythooren, Stijn Ghijselings, Jordi Cools, Melissa Depypere, Paul De Munter, Willem-Jan Metsemakers, and Georges Vles
J. Bone Joint Infect., 8, 209–218, https://doi.org/10.5194/jbji-8-209-2023,https://doi.org/10.5194/jbji-8-209-2023, 2023
Short summary
Wound drainage after arthroplasty and prediction of acute prosthetic joint infection: prospective data from a multicentre cohort study using a telemonitoring app
Henk Scheper, Rachid Mahdad, Brenda Elzer, Claudia Löwik, Wierd Zijlstra, Taco Gosens, Joris C. T. van der Lugt, Robert J. P. van der Wal, Rudolf W. Poolman, Matthijs P. Somford, Paul C. Jutte, Pieter K. Bos, Richard E. Zwaan, Rob G. H. H. Nelissen, Leo G. Visser, Mark G. J. de Boer, and the wound care app study group
J. Bone Joint Infect., 8, 59–70, https://doi.org/10.5194/jbji-8-59-2023,https://doi.org/10.5194/jbji-8-59-2023, 2023
Short summary
The unrelenting tide of osteoarticular infections in children: reflections from Uganda, eastern Africa
Antonio Loro
J. Bone Joint Infect., 7, 183–185, https://doi.org/10.5194/jbji-7-183-2022,https://doi.org/10.5194/jbji-7-183-2022, 2022
Short summary
Arthroplasty after septic arthritis of the native hip and knee: retrospective analysis of 49 joints
Elodie Portier, Valérie Zeller, Younes Kerroumi, Beate Heym, Simon Marmor, and Pascal Chazerain
J. Bone Joint Infect., 7, 81–90, https://doi.org/10.5194/jbji-7-81-2022,https://doi.org/10.5194/jbji-7-81-2022, 2022
Short summary
The presence of a draining sinus is associated with failure of re-implantation during two-stage exchange arthroplasty
Alexandra S.​​​​​​​ Gabrielli, Alan E. Wilson, Richard A. Wawrose, Malcolm Dombrowski, Michael J. O'Malley, and Brian A. Klatt
J. Bone Joint Infect., 7, 55–60, https://doi.org/10.5194/jbji-7-55-2022,https://doi.org/10.5194/jbji-7-55-2022, 2022
Short summary

Cited articles

Achermann, Y., Eigenmann, K., Ledergerber, B., Derksen, L., Rafeiner, P., Clauss, M., Nüesch, R., Zellweger, C., Vogt, M., and Zimmerli, W.: Factors associated with rifampin resistance in staphylococcal periprosthetic joint Infections (PJI): A matched case–control study, Infection, 41, 431–437, https://doi.org/10.1007/s15010-012-0325-7, 2013. 
Goldstein, B. P.: Resistance to Rifampicin: A Review, J. Antibiot., 67, 625–630, https://doi.org/10.1038/ja.2014.107, 2014. 
Hellmark, B., Unemo, M., Nilsdotter-Augustinsson, Å., and Söderquist, B.: Antibiotic Susceptibility among Staphylococcus Epidermidis Isolated from Prosthetic Joint Infections with Special Focus on Rifampicin and Variability of the RpoB Gene, Clin. Microbiol. Infec., 15, 238–244, https://doi.org/10.1111/j.1469-0691.2008.02663.x, 2009. 
Ju, O., Woolley, M., and Gordon, D.: Emergence and Spread of Rifampicin-Resistant, Methicillin-Resistant Staphylococcus Aureus during Vancomycin–Rifampicin Combination Therapy in an Intensive Care Unit, Eur. J. Clin. Microbiol. Infect. Dis., 25, 61–62, https://doi.org/10.1007/s10096-005-0063-1, 2006. 
Lai, C. C., Che-Kim, T., Sheng-Hsiang, L., Chun-Hsing, L., Yu-Tsung, H., and Po-Ren, H.: Emergence of rifampicin resistance during rifampicin-containing treatment in elderly patients with persistent methicillin-resistant staphylococcus aureus bacteremia, J. Am. Geriatr. Soc., 58, 1001–1003, https://doi.org/10.1111/j.1532-5415.2010.02842.x, 2010. 
Download
Short summary
Skin commensal bacteria such as staphylococci are often the source of orthopaedic-device-related infections. Rifampicin is a widely used antibiotic in the treatment of these infections. The results of this study show that oral rifampicin therapy leads to a consistent and persistent induction of resistance in commensal staphylococci on the skin and in the nose for a prolonged time.