Journal of Bone and Joint Infection
Journal of Bone and Joint Infection
JBJI
Articles | Volume 9, issue 4
Articles | Volume 9, issue 4
https://doi.org/10.5194/jbji-9-191-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-9-191-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 9, issue 4
Brief report
 | 
24 Jul 2024
Brief report |  | 24 Jul 2024

Emergence of rifampicin-resistant staphylococci on the skin and nose of rifampicin-treated patients with an orthopaedic-device-related infection

Alexandra Wallimann, Yvonne Achermann, Ciara Ferris, Mario Morgenstern, Martin Clauss, Vincent Stadelmann, Hannes Andreas Rüdiger, Liam O'Mahony, and Thomas Fintan Moriarty

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Achermann, Y., Eigenmann, K., Ledergerber, B., Derksen, L., Rafeiner, P., Clauss, M., Nüesch, R., Zellweger, C., Vogt, M., and Zimmerli, W.: Factors associated with rifampin resistance in staphylococcal periprosthetic joint Infections (PJI): A matched case–control study, Infection, 41, 431–437, https://doi.org/10.1007/s15010-012-0325-7, 2013. 
Goldstein, B. P.: Resistance to Rifampicin: A Review, J. Antibiot., 67, 625–630, https://doi.org/10.1038/ja.2014.107, 2014. 
Hellmark, B., Unemo, M., Nilsdotter-Augustinsson, Å., and Söderquist, B.: Antibiotic Susceptibility among Staphylococcus Epidermidis Isolated from Prosthetic Joint Infections with Special Focus on Rifampicin and Variability of the RpoB Gene, Clin. Microbiol. Infec., 15, 238–244, https://doi.org/10.1111/j.1469-0691.2008.02663.x, 2009. 
Ju, O., Woolley, M., and Gordon, D.: Emergence and Spread of Rifampicin-Resistant, Methicillin-Resistant Staphylococcus Aureus during Vancomycin–Rifampicin Combination Therapy in an Intensive Care Unit, Eur. J. Clin. Microbiol. Infect. Dis., 25, 61–62, https://doi.org/10.1007/s10096-005-0063-1, 2006. 
Lai, C. C., Che-Kim, T., Sheng-Hsiang, L., Chun-Hsing, L., Yu-Tsung, H., and Po-Ren, H.: Emergence of rifampicin resistance during rifampicin-containing treatment in elderly patients with persistent methicillin-resistant staphylococcus aureus bacteremia, J. Am. Geriatr. Soc., 58, 1001–1003, https://doi.org/10.1111/j.1532-5415.2010.02842.x, 2010. 
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Short summary
Skin commensal bacteria such as staphylococci are often the source of orthopaedic-device-related infections. Rifampicin is a widely used antibiotic in the treatment of these infections. The results of this study show that oral rifampicin therapy leads to a consistent and persistent induction of resistance in commensal staphylococci on the skin and in the nose for a prolonged time. 
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