Articles | Volume 9, issue 3
https://doi.org/10.5194/jbji-9-149-2024
https://doi.org/10.5194/jbji-9-149-2024
Original full-length article
 | 
04 Jun 2024
Original full-length article |  | 04 Jun 2024

Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study

Jaap L. J. Hanssen, Robert J. P. van der Wal, Henrica M. J. van der Linden, Joffrey van Prehn, Henk Scheper, and Mark G. J. de Boer

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Cited articles

Bene, N., Li, X., and Nandi, S.: Increased antibiotic duration improves reoperation free survival after total hip arthroplasty irrigation and debridement, J. Orthop., 15, 707–710, https://doi.org/10.1016/j.jor.2018.05.014, 2018. 
Bryan, A. J., Abdel, M. P., Sanders, T. L., Fitzgerald, S. F., Hanssen, A. D., and Berry, D. J.: Irrigation and Debridement with Component Retention for Acute Infection After Hip Arthroplasty, J. Bone Joint Surg., 99, 2011–2018, https://doi.org/10.2106/jbjs.16.01103, 2017. 
Byren, I., Bejon, P., Atkins, B. L., Angus, B., Masters, S., McLardy-Smith, P., Gundle, R., and Berendt, A.: One hundred and twelve infected arthroplasties treated with “DAIR” (debridement, antibiotics and implant retention): antibiotic duration and outcome, J. Antimicrob. Chemoth., 63, 1264–1271, https://doi.org/10.1093/jac/dkp107, 2009. 
Ceccarelli, G., Perciballi, B., Russo, A., Martini, P., Marchetti, F., Capparuccia, M. R., Iaiani, G., Fabris, S., Ciccozzi, M., Villani, C., Venditti, M., D'Ettorre, G., and De Meo, D.: Chronic Suppressive Antibiotic Treatment for Staphylococcal Bone and Joint Implant-Related Infections, Antibiotics, 12, 937, https://doi.org/10.3390/antibiotics12050937, 2023. 
Cobo, J. and Escudero-Sanchez, R.: Suppressive Antibiotic Treatment in Prosthetic Joint Infections: A Perspective, Antibiotics, 10, 743, https://doi.org/10.3390/antibiotics10060743, 2021. 
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Short summary
Some patients with an infection of their orthopedic implant use lifelong daily antibiotics. Our research, however, suggests that it might be safe to stop after 2 to 3 years. Furthermore, we found that it is probably safe to use a lower dosage of antibiotics than normally used for these infections. We performed this study by retrospectively analyzing electronic patient files from all patients we treated in our hospital with suppressive antibiotics.