Articles | Volume 9, issue 2
30 Apr 2024
Review |  | 30 Apr 2024

Sex-related differences in periprosthetic joint infection research

Domenico De Mauro, Cesare Meschini, Giovanni Balato, Tiziana Ascione, Enrico Festa, Davide Bizzoca, Biagio Moretti, Giulio Maccauro, and Raffaele Vitiello

Related subject area

Subject: Prosthesis-related infections | Topic: Epidemiology
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Pansachee Damronglerd, Eibhlin Higgins, Madiha Fida, Don Bambino Geno Tai, Aaron J. Tande, Matthew P. Abdel, and Omar M. Abu Saleh
J. Bone Joint Infect., 9, 99–106,,, 2024
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Sex-specific analysis of clinical features and outcomes in staphylococcal periprosthetic joint infections managed with two-stage exchange arthroplasty
Eibhlin Higgins, Don Bambino Geno Tai, Brian Lahr, Gina A. Suh, Elie F. Berbari, Kevin I. Perry, Matthew P. Abdel, and Aaron J. Tande
J. Bone Joint Infect., 8, 125–131,,, 2023
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Characteristics and outcomes of culture-negative prosthetic joint infections from the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort study
Sarah Browning, Laurens Manning, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clark, and Joshua S. Davis
J. Bone Joint Infect., 7, 203–211,,, 2022
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Has the time come for regional periprosthetic joint infection centers in the United States? A first-year experience
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Cited articles

Balato, G., Roscetto, E., Vollaro, A., Galasso, O., Gasparini, G., Ascione, T., Catania, M. R., and Mariconda, M.: Bacterial biofilm formation is variably inhibited by different formulations of antibiotic-loaded bone cement in vitro, Knee Surg. Sports Traumatol. Arthrosc. Off. J. ESSKA, 27, 1943–1952,, 2019a. 
Balato, G., Barbaric, K., Bićanić, G., Bini, S., Chen, J., Crnogaca, K., Kenanidis, E., Giori, N., Goel, R., Hirschmann, M., Marcacci, M., Amat Mateu, C., Nam, D., Shao, H., Shen, B., Tarabichi, M., Tarabichi, S., Tsiridis, E., and Tzavellas, A.-N.: Hip and Knee Section, Prevention, Surgical Technique: Proceedings of International Consensus on Orthopedic Infections, J. Arthroplasty, 34, S301–S307,, 2019b. 
Basilico, M., Vitiello, R., Oliva, M. S., Covino, M., Greco, T., Cianni, L., Dughiero, G., Ziranu, A., Perisano, C., and Maccauro, G.: Predictable risk factors for infections in proximal femur fractures, J. Biol. Regul. Homeost. Agents, 34, 77–81, 2020. 
Bizzoca, D., Solarino, G., Pulcrano, A., Brunetti, G., Moretti, A. M., Moretti, L., Piazzolla, A., and Moretti, B.: Gender-Related Issues in the Management of Low-Back Pain: A Current Concepts Review, Clin. Pract., 13, 1360–1368,, 2023. 
Bouji, N., Wen, S., and Dietz, M. J.: Intravenous antibiotic duration in the treatment of prosthetic joint infection: systematic review and meta-analysis, J. Bone Joint Infect., 7, 191–202,, 2022. 
Short summary
This study investigates sex-related differences in periprosthetic Joint Infections (PJIs) after total joint arthroplasty. A systematic review of nine studies reveals a higher risk of infectious complications in males compared to females, as indicated by statistically significant findings in half of the studies. This underscores the need for ongoing sex-related analysis to enhance evidence and insights in the field of PJIs.