Articles | Volume 8, issue 6
Original full-length article
03 Nov 2023
Original full-length article |  | 03 Nov 2023

Frequent microbiological profile changes are seen in subsequent-revision hip and knee arthroplasty for prosthetic joint infection

Robert A. McCulloch, Alex Martin, Bernadette C. Young, Benjamin J. Kendrick, Abtin Alvand, Lee Jeys, Jonathan Stevenson, and Antony J. Palmer

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Cited articles

Ali, F., Wilkinson, J. M., Cooper, J. R., Kerry, R. M., Hamer, A. J., Norman, P., and Stockley, I.: Accuracy of Joint Aspiration for the Preoperative Diagnosis of Infection in Total Hip Arthroplasty, J. Arthroplasty, 21, 221–226, 2006. 
Citak, M., Friedenstab, J., Abdelaziz, H., Suero, E. M., Zahar, A., Salber, J., and Gehrke, T.: Risk Factors for Failure After 1-Stage Exchange Total Knee Arthroplasty in the Management of Periprosthetic Joint Infection, J. Bone Joint Surg., 101, 1061–1069, 2019. 
Corrigan, R. A., Sliepen, J., Dudareva, M., IJpma, F. F. A., Govaert, G., Atkins, B. L., Rentenaar, R., Wouthuyzen-Bakker, M., and McNally, M.: Causative Pathogens Do Not Differ between Early, Delayed or Late Fracture-Related Infections, Antibiotics, 11, 943,, 2022. 
Gerritsen, M., Khawar, A., Scheper, H., van der Wal, R., Schoones, J., de Boer, M., Nelissen, R., and Pijls, B.: Modular component exchange and outcome of DAIR for hip and knee periprosthetic joint infection, Bone Joint Open, 2, 806–812, 2021. 
Short summary
Patients undergoing multiple hip and knee revision arthroplasty procedures for periprosthetic joint infection can have a changing microbiological picture, which can impact their management and outcomes. We aimed to investigate this using data from two large-volume orthopaedic centres. A total of 106 patients were identified; after six revision procedures, 90 % of patients had different organisms cultured compared with the initial revision and 53 % of the organisms were multidrug resistant.