Simple and inexpensive synovial fluid biomarkers for the diagnosis of prosthetic joint infection according to the new EBJIS definition

Diniz, Sara Elisa; Ribau, Ana; Vinha, André; Oliveira, José Carlos; Abreu, Miguel Araújo; Sousa, Ricardo

doi:https://doi.org/10.5194/jbji-8-109-2023

Articles | Volume 8, issue 2

https://doi.org/10.5194/jbji-8-109-2023

© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/jbji-8-109-2023

© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 8, issue 2

Original full-length article

|

29 Mar 2023

Original full-length article |

| 29 Mar 2023

Simple and inexpensive synovial fluid biomarkers for the diagnosis of prosthetic joint infection according to the new EBJIS definition

Sara Elisa Diniz, Ana Ribau, André Vinha, José Carlos Oliveira, Miguel Araújo Abreu, and Ricardo Sousa

Related authors

Differential synovial fluid white blood cell count for the diagnosis of chronic peri-prosthetic joint infection – a systematic review and meta-analysis

Marta Sabater-Martos, Martin Clauss, Ana Ribau, Ricardo Sousa, and on behalf of the Leukocyte Count Synovial Fluid working group for the Unified PJI definition task force

J. Bone Joint Infect., 10, 165–184, https://doi.org/10.5194/jbji-10-165-2025,https://doi.org/10.5194/jbji-10-165-2025, 2025

Short summary

Debridement, antimicrobial therapy, and implant retention (DAIR) as curative surgical strategy for acute periprosthetic hip and knee infections: a summary of the position paper from the European Bone & Joint Infection Society (EBJIS)

Irene K. Sigmund, Marjan Wouthuyzen-Bakker, Tristan Ferry, Willem-Jan Metsemakers, Martin Clauss, Alex Soriano, Rihard Trebse, and Ricardo Sousa

J. Bone Joint Infect., 10, 139–142, https://doi.org/10.5194/jbji-10-139-2025,https://doi.org/10.5194/jbji-10-139-2025, 2025

Short summary

Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)

Irene K. Sigmund, Tristan Ferry, Ricardo Sousa, Alex Soriano, Willem-Jan Metsemakers, Martin Clauss, Rihard Trebse, and Marjan Wouthuyzen-Bakker

J. Bone Joint Infect., 10, 101–138, https://doi.org/10.5194/jbji-10-101-2025,https://doi.org/10.5194/jbji-10-101-2025, 2025

Short summary

Predicting periprosthetic joint infection: external validation of preoperative prediction models

Seung-Jae Yoon, Paul C. Jutte, Alex Soriano, Ricardo Sousa, Wierd P. Zijlstra, and Marjan Wouthuyzen-Bakker

J. Bone Joint Infect., 9, 231–239, https://doi.org/10.5194/jbji-9-231-2024,https://doi.org/10.5194/jbji-9-231-2024, 2024

Short summary

Guideline for management of septic arthritis in native joints (SANJO)

Christen Ravn, Jeroen Neyt, Natividad Benito, Miguel Araújo Abreu, Yvonne Achermann, Svetlana Bozhkova, Liselotte Coorevits, Matteo Carlo Ferrari, Karianne Wiger Gammelsrud, Ulf-Joachim Gerlach, Efthymia Giannitsioti, Martin Gottliebsen, Nis Pedersen Jørgensen, Tomislav Madjarevic, Leonard Marais, Aditya Menon, Dirk Jan Moojen, Markus Pääkkönen, Marko Pokorn, Daniel Pérez-Prieto, Nora Renz, Jesús Saavedra-Lozano, Marta Sabater-Martos, Parham Sendi, Staffan Tevell, Charles Vogely, Alex Soriano, and the SANJO guideline group

J. Bone Joint Infect., 8, 29–37, https://doi.org/10.5194/jbji-8-29-2023,https://doi.org/10.5194/jbji-8-29-2023, 2023

Short summary

Cited articles

Amanatullah, D. F., Cheng, R. Z., Huddleston Iii, J. I., Maloney, W. J., Finlay, A. K., Kappagoda, S., Suh, G. A., and Goodman, S. B.: The routine use of synovial alpha-defensin is not necessary, Bone Joint J., 102-B, 593–599, https://doi.org/10.1302/0301-620X.102B5.BJJ-2019-0473.R3, 2020.

Chen, Y., Kang, X., Tao, J., Zhang, Y., Ying, C., and Lin, W.: Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis, J. Orthop. Surg. Res., 14, 453, https://doi.org/10.1186/s13018-019-1395-3, 2019.

Deirmengian, C., Kardos, K., Kilmartin, P., Cameron, A., Schiller, K., and Parvizi, J.: Combined measurement of synovial fluid alpha-Defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection, J. Bone Joint Surg. Am., 96, 1439–1445, https://doi.org/10.2106/JBJS.M.01316, 2014.

De Vecchi, E., Romano, C.L., De Grandi, R., Cappelletti, L., Villa, F., and Drago, L.: Alpha defensin, leukocyte esterase, C-reactive protein, and leukocyte count in synovial fluid for pre-operative diagnosis of periprosthetic infection, Int. J. Immunopath. Ph., 32, 2058738418806072, https://doi.org/10.1177/2058738418806072, 2018.

Dinneen, A., Guyot, A., Clements, J., and Bradley, N.: Synovial fluid white cell and differential count in the diagnosis or exclusion of prosthetic joint infection, Bone Joint J., 95-B, 554–557, https://doi.org/10.1302/0301-620X.95B4.30388, 2013.