Articles | Volume 7, issue 5
Original full-length article
20 Sep 2022
Original full-length article |  | 20 Sep 2022

Characteristics and outcomes of culture-negative prosthetic joint infections from the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort study

Sarah Browning, Laurens Manning, Sarah Metcalf, David L. Paterson, James O. Robinson, Benjamin Clark, and Joshua S. Davis

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Cited articles

Alijanipour, P., Adeli, B., Hansen, E. N., Chen, A. F., and Parvizi, J.: Intraoperative purulence is not reliable for diagnosing periprosthetic joint infection, J Arthroplasty, 30, 1403–1406, 2015. 
Berbari, E. F., Marculescu, C., Sia, I., Lahr, B. D., Hanssen, A. D., Steckelberg, J. M., Gullerud, R., and Osmon, D. R.: Culture-Negative Prosthetic Joint Infection, Clin. Infect. Dis., 45, 1113–1119,, 2007. 
Choi, H.-R., Kwon, Y.-M., Freiberg, A. A., Nelson, S. B., and Malchau, H.: Periprosthetic joint infection with negative culture results: clinical characteristics and treatment outcome, J. Arthroplasty, 28, 899–903, 2013. 
Del Pozo, J. L. and Patel, R.: Infection Associated with Prosthetic Joints, New Engl. J. Med., 361, 787–794,, 2009. 
Short summary
Culture-negative (CN) prosthetic joint infections (PJIs) present significant challenges for clinicians. While previous retrospective analyses have been conducted, inconsistencies in inclusion criteria and treatment success measures limit the opportunity for direct comparisons and use in guiding clinical practice. We compared baseline characteristics and outcomes of CN with culture-positive (CP) cases in a large multicentre prospective cohort and demonstrated improved overall outcomes in CN PJI.