Articles | Volume 6, issue 9
J. Bone Joint Infect., 6, 413–421, 2021
https://doi.org/10.5194/jbji-6-413-2021
J. Bone Joint Infect., 6, 413–421, 2021
https://doi.org/10.5194/jbji-6-413-2021

Original full-length article 12 Nov 2021

Original full-length article | 12 Nov 2021

Mid-term clinical results of chronic cavitary long bone osteomyelitis treatment using S53P4 bioactive glass: a multi-center study

Tom A. G. Van Vugt et al.

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Cited articles

Blaha, J. D., Calhoun, J. H., Nelson, C. L., Henry, S. L., Seligson, D., Esterhai, J. L., Jr., Heppenstall, R. B., Mader, J., Evans, R. P., and Wilkins, J.: Comparison of the clinical efficacy and tolerance of gentamicin PMMA beads on surgical wire versus combined and systemic therapy for osteomyelitis, Clin. Orthop. Relat. Res., 295, 8–12, 1993. 
Bortolin, M., De Vecchi, E., Romano, C. L., Toscano, M., Mattina, R., and Drago, L.: Antibiofilm agents against MDR bacterial strains: is bioactive glass BAG-S53P4 also effective?, J. Antimicrob. Chemother., 71, 123–127, https://doi.org/10.1093/jac/dkv327, 2016. 
Cierny III, G., Mader, J. T., and Penninck, J. J.: A clinical staging system for adult osteomyelitis, Clin. Orthop. Relat. Res., 414, 7–24, https://doi.org/10.1097/01.blo.0000088564.81746.62, 2003. 
Coraca-Huber, D. C., Fille, M., Hausdorfer, J., Putzer, D., and Nogler, M.: Efficacy of antibacterial bioactive glass S53P4 against S. aureus biofilms grown on titanium discs in vitro, J. Orthop. Res., 32, 175–177, https://doi.org/10.1002/jor.22463, 2014. 
Detsch, R., Stoor, P., Grunewald, A., Roether, J. A., Lindfors, N. C., and Boccaccini, A. R.: Increase in VEGF secretion from human fibroblast cells by bioactive glass S53P4 to stimulate angiogenesis in bone, J. Biomed. Mater. Res. A, 102, 4055–4061, https://doi.org/10.1002/jbm.a.35069, 2014. 
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Short summary
Chronic osteomyelitis is a bone infection and was treated with a combination of antibiotics and two surgeries. With the introduction of the biomaterial S53P4 bioactive glass, these infections can be treated with antibiotics and one surgery. This study shows 85 % success in the treatment of these bone infections. Together with the fundamentally different antibacterial mechanisms without antibiotic resistance, S53P4 bioactive glass is recommendable for the treatment of these infections.