Articles | Volume 6, issue 9
https://doi.org/10.5194/jbji-6-413-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/jbji-6-413-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Mid-term clinical results of chronic cavitary long bone osteomyelitis treatment using S53P4 bioactive glass: a multi-center study
Tom A. G. Van Vugt
Department of Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands
Jeffrey Heidotting
Department of Orthopedic Surgery, University Medical Center Groningen (UMCG), Groningen, the Netherlands
Jacobus J. Arts
Department of Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands
Department of Biomedical Engineering (research group Orthopaedic Biomechanics), Eindhoven University of Technology, Eindhoven, the Netherlands
Joris J. W. Ploegmakers
Department of Orthopedic Surgery, University Medical Center Groningen (UMCG), Groningen, the Netherlands
Paul C. Jutte
Department of Orthopedic Surgery, University Medical Center Groningen (UMCG), Groningen, the Netherlands
Department of Orthopedic Surgery, CAPHRI Care and Public Health Research Institute, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands
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Georges F. Vles, Willem-Jan Metsemakers, Laurens Aerden, Jan Geurts, Oliver Borens, and Stijn Ghijselings
J. Bone Joint Infect., 11, 547–554, https://doi.org/10.5194/jbji-11-547-2026, https://doi.org/10.5194/jbji-11-547-2026, 2026
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We studied three patients who had both a broken femur and a long-standing infection around an artificial hip, a rare and difficult problem. We treated them in two steps: first removing the implant, cleaning the infection, stabilizing the bone, and placing a temporary bone cement spacer; and then reimplanting the hip prosthesis once infection was controlled. In all cases, the infection cleared, the bone healed, and function improved. This approach may offer a safe way to manage these complex cases.
Seung-Jae Yoon, Paul C. Jutte, Alex Soriano, Ricardo Sousa, Wierd P. Zijlstra, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 9, 231–239, https://doi.org/10.5194/jbji-9-231-2024, https://doi.org/10.5194/jbji-9-231-2024, 2024
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This study validated three models for predicting infection after hip and knee replacement surgery. By analyzing data from 2684 patients in the Netherlands, Portugal, and Spain, we found that the models developed by Tan, Del Toro, and Bülow effectively identified high-risk patients. These models can be used to enhance preoperative counseling and to tailor infection prevention measures individually, potentially improving outcomes and reducing healthcare costs.
Henk Scheper, Rachid Mahdad, Brenda Elzer, Claudia Löwik, Wierd Zijlstra, Taco Gosens, Joris C. T. van der Lugt, Robert J. P. van der Wal, Rudolf W. Poolman, Matthijs P. Somford, Paul C. Jutte, Pieter K. Bos, Richard E. Zwaan, Rob G. H. H. Nelissen, Leo G. Visser, Mark G. J. de Boer, and the wound care app study group
J. Bone Joint Infect., 8, 59–70, https://doi.org/10.5194/jbji-8-59-2023, https://doi.org/10.5194/jbji-8-59-2023, 2023
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The relation between postoperative wound leakage and occurrence of a prosthetic joint infection (PJI) after arthroplasty has not been investigated in a prospective study. We performed a large cohort study in which 1019 patients, after arthroplasty, recorded their wound drainage status in a wound care app during 30 postoperative days. Risk factors for wound drainage were identified. Moderate to heavy wound leakage in the third postoperative week was strongly associated with the occurrence of PJI.
Jorrit Willem Adriaan Schoenmakers, Rosanne de Boer, Lilli Gard, Greetje Anna Kampinga, Marleen van Oosten, Jan Maarten van Dijl, Paulus Christiaan Jutte, and Marjan Wouthuyzen-Bakker
J. Bone Joint Infect., 8, 45–50, https://doi.org/10.5194/jbji-8-45-2023, https://doi.org/10.5194/jbji-8-45-2023, 2023
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In a first evaluation, the accuracy of a novel multiplex PCR (polymerase chain reaction) panel for rapid detection of pathogens in patients with a clinical suspicion of acute septic arthritis of native and prosthetic joints is assessed. Clear benefit is seen in patients with a suspected native septic arthritis and late acute prosthetic joint infection. This indicates that the panel allows for fast tailoring of antibiotics and may prompt the surgeon for surgical lavage in doubtful clinical cases.
Karsten D. Ottink, Stefan J. Gelderman, Marjan Wouthuyzen-Bakker, Joris J. W. Ploegmakers, Andor W. J. M. Glaudemans, and Paul C. Jutte
J. Bone Joint Infect., 7, 1–9, https://doi.org/10.5194/jbji-7-1-2022, https://doi.org/10.5194/jbji-7-1-2022, 2022
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A low-grade periprosthetic joint infection (PJI) may be difficult to diagnose, and nuclear imaging could help in the diagnosis. However, its diagnostic value is unclear. We retrospectively evaluated this diagnostic value. We conclude that in patients presenting with nonspecific symptoms and a low a priori chance of PJI based on clinical evaluation, nuclear imaging is of no clear added value in diagnosing a PJI.
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Short summary
Chronic osteomyelitis is a bone infection and was treated with a combination of antibiotics and two surgeries. With the introduction of the biomaterial S53P4 bioactive glass, these infections can be treated with antibiotics and one surgery. This study shows 85 % success in the treatment of these bone infections. Together with the fundamentally different antibacterial mechanisms without antibiotic resistance, S53P4 bioactive glass is recommendable for the treatment of these infections.
Chronic osteomyelitis is a bone infection and was treated with a combination of antibiotics and...