Journal cover Journal topic
Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
Journal topic
Volume 5, issue 4
J. Bone Joint Infect., 5, 198–204, 2020
https://doi.org/10.7150/jbji.45338
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 5, 198–204, 2020
https://doi.org/10.7150/jbji.45338
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

Review 23 Jun 2020

Review | 23 Jun 2020

Surgical techniques for Bone Biopsy in Diabetic Foot Infection, and association between results and treatment duration

Eric Senneville1,2, Donatienne Joulie2,3, Nicolas Blondiaux2,4, and Olivier Robineau1,2 Eric Senneville et al.
  • 1Infectious Diseases Department Gustave Dron Hospital F-59200 Tourcoing, and Lille University F-59000, Lille, France.
  • 2Northern-West French National Referent Centre for Complex Bone and Joint Infections (CRIOAC Lille-Tourcoing).
  • 3Orthopaedic Surgery Department G. Dron Hospital Tourcoing F-59200 Tourcoing France.
  • 4Microbiology Laboratory G. Dron Hospital Tourcoing F-59200 Tourcoing France.

Keywords: diabetic foot osteomyelitis, bone margins biopsy, outcome, antibiotic therapy, surgery

Abstract. Surgery is an important part of the management of patients diagnosed with DFO. It consists in some selected patients, to remove all or part of the infected bone(s) or even to amputate all or part of the foot. Despite the use of sophisticated imaging techniques, it is however difficult to remove all the infected tissue while respecting the principles of an economical surgery. Bone biopsy performed at the margins of the resection permits to identify residual osteomyelitis and to adjust the post-surgical antibiotic treatment. Some recent studies have reported the way to perform bone margin biopsies and have assessed the impact of the bone results on the patient's outcome. However, the real impact of a residual osteomyelitis on the risk of recurrent DFO is still debated and questions regarding the interpretation of the results remain to be solved. Similarly, the consequences in terms of choice and duration of the antimicrobial treatment to use in case of positive bone margin are not clearly established.

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