Journal cover Journal topic
Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
Journal topic
Volume 5, issue 4
J. Bone Joint Infect., 5, 172–175, 2020
https://doi.org/10.7150/jbji.44848
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 5, 172–175, 2020
https://doi.org/10.7150/jbji.44848
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

Brief report 25 May 2020

Brief report | 25 May 2020

Staphylococcus argenteus as an etiological agent of prosthetic hip joint infection: a case presentation

Bo Söderquist1, Peter Wildeman1,2, Bianca Stenmark1, and Marc Stegger1,3 Bo Söderquist et al.
  • 1Department of Laboratory Medicine, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden.
  • 2Department of Orthopedics, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden.
  • 3Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Keywords: prosthetic joint infections, antimicrobial agents, genome analysis, Staphylococcus argenteus

Abstract. This report presents a case of prosthetic hip infection caused by Staphylococcus argenteus, a potentially overlooked etiology of prosthetic joint infections (PJIs). Whole-genome sequencing showed that the S. argenteus isolate was an ST2250 and clustered within other CC2250 isolates, the largest clonal group of S. argenteus. This sequence type is prevalent and may be associated with invasive infections. The present isolate was phenotypically fully susceptible to all tested antimicrobial agents and genome analysis did not detect any resistance genes, nor were any staphylococcal cassette chromosome residues detected. Despite initial appropriate management with debridement and biofilm-active antibiotics, the outcome was unfavorable with recurrence and a persistent infection treated with suppressive antibiotics. Regarding the repertoire of genomic traits for virulence in S. argenteus, PJIs caused by this bacterium should be treated accordingly as Staphylococcus aureus PJIs.

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