JBJI Journal of Bone and Joint Infection JBJI J. Bone Joint Infect. 2206-3552 Ivyspring Göttingen, Germany 10.7150/jbji.44848 <em>Staphylococcus argenteus</em> as an etiological agent of prosthetic hip joint infection: a case presentation Söderquist Bo 1 Wildeman Peter 1 2 Stenmark Bianca 1 Stegger Marc 1 3 Department of Laboratory Medicine, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden. Department of Orthopedics, Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden. Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark. 25 05 2020 5 4 172 175 Copyright: © 2020 Bo Söderquist et al. 2020 This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ This article is available from https://jbji.copernicus.org/articles/5/172/2020/jbji-5-172-2020.html The full text article is available as a PDF file from https://jbji.copernicus.org/articles/5/172/2020/jbji-5-172-2020.pdf

<p class="p p-first-last" id="idm139955168966464">This report presents a case of prosthetic hip infection caused by <em>Staphylococcus argenteus,</em> a potentially overlooked etiology of prosthetic joint infections (PJIs). Whole-genome sequencing showed that the <em>S. argenteus</em> isolate was an ST2250 and clustered within other CC2250 isolates, the largest clonal group of <em>S. argenteus</em>. This sequence type is prevalent and may be associated with invasive infections. The present isolate was phenotypically fully susceptible to all tested antimicrobial agents and genome analysis did not detect any resistance genes, nor were any staphylococcal cassette chromosome residues detected. Despite initial appropriate management with debridement and biofilm-active antibiotics, the outcome was unfavorable with recurrence and a persistent infection treated with suppressive antibiotics. Regarding the repertoire of genomic traits for virulence in <em>S. argenteus</em>, PJIs caused by this bacterium should be treated accordingly as <em>Staphylococcus aureus</em> PJIs.</p>

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