Current Insights in the Application of Bone Grafts for Local Antibiotic Delivery in Bone Reconstruction Surgery

Peeters, Arne; Putzeys, Guy; Thorrez, Lieven

doi:https://doi.org/10.7150/jbji.38373

Articles | Volume 4, issue 5

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Articles | Volume 4, issue 5

https://doi.org/10.7150/jbji.38373

Articles | Volume 4, issue 5

Article
Metrics
Related articles

Review

15 Oct 2019

Review |

| 15 Oct 2019

Current Insights in the Application of Bone Grafts for Local Antibiotic Delivery in Bone Reconstruction Surgery

Arne Peeters, Guy Putzeys, and Lieven Thorrez

Arne Peeters

Faculty of Medicine, KU Leuven, Leuven, Belgium

Guy Putzeys

Orthopedic Centre, AZ Groeninge, Kortrijk, Belgium

Lieven Thorrez

Department of Development and Regeneration, KU Leuven, Kortrijk, Belgium

Cited articles

Kremers HM, Nwojo ME, Ransom JE, Wood-Wentz CM, Melton LJ, Huddleston PM. Trends in the Epidemiology of Osteomyelitis. J Bone Jt Surg. 2015;97(10):837–845. [PMC free article]

Gwam CU, Mistry JB, Mohamed NS, Thomas M, Bigart KC, Mont MA. et al. Current Epidemiology of Revision Total Hip Arthroplasty in the United States: National Inpatient Sample 2009 to 2013. J Arthroplasty Churchill Livingstone. 2017;32(7):2088–2092.

Delanois RE, Mistry JB, Gwam CU, Mohamed NS, Choksi US, Mont MA. Current Epidemiology of Revision Total Knee Arthroplasty in the United States. J Arthroplasty. 2017;32(9):2663–2668.

Kapadia BH, Berg RA, Daley JA, Fritz J, Bhave A, Mont MA. Periprosthetic joint infection. Lancet. 2016;387(10016):386–394.

Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030. J Bone Jt Surg. 2007;89(4):780.

Metsemakers W-J, Onsea J, Neutjens E, Steffens E, Schuermans A, McNally M. et al. Prevention of fracture-related infection: a multidisciplinary care package. Int Orthop Springer Berlin Heidelberg. 2017;41(12):2457–2469.

Lebeaux D, Ghigo J-M, Beloin C. Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Microbiol Mol Biol Rev American Society for Microbiology. 2014;78(3):510–43. [PMC free article]

Macia MD, Rojo-Molinero E, Oliver A. Antimicrobial susceptibility testing in biofilm-growing bacteria. Clin Microbiol Infect Elsevier. 2014;20(10):981–990.

Hierholzer G, Rehn J, Knothe H, Masterson J. Antibiotic therapy of chronic post-traumatic osteomyelitis. J Bone Joint Surg Br. 1974;56(-B4):721–9.

Calhoun JH, Manring MM. Adult Osteomyelitis. Infect Dis Clin North Am Elsevier. 2005;19(4):765–786.

Aggarwal VK, Rasouli MR, Parvizi J. Periprosthetic joint infection: Current concept. Indian J Orthop Wolters Kluwer - Medknow Publications. 2013;47(1):10–7. [PMC free article]

Gálvez-López R, Peña-Monje A, Antelo-Lorenzo R, Guardia-Olmedo J, Moliz J, Hernández-Quero J. et al. Elution kinetics, antimicrobial activity, and mechanical properties of 11 different antibiotic loaded acrylic bone cement. Diagn Microbiol Infect Dis. 2014;78(1):70–74.

Anagnostakos K, Hitzler P, Pape D, Kohn D, Kelm J. Persistence of bacterial growth on antibiotic-loaded beads: Is it actually a problem? Acta Orthop Taylor & Francis. 2008;79(2):302–307.

Inzana JA, Schwarz EM, Kates SL, Awad HA. Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials Elsevier. 2016;81:58–71. [PMC free article]

Post V, Wahl P, Richards RG, Moriarty TF. Vancomycin displays time-dependent eradication of mature Staphylococcus aureus biofilms. J Orthop Res. 2017;35(2):381–388.

Perry CR. Bone repair techniques, bone graft, and bone graft substitutes. Clin Orthop Relat Res. 1999;(360):71–86.

Frommelt L. Anwendung von Antibiotika im Knochen. Orthopade. 2018;47(1):24–29.

Witsø E, Persen L, Løseth K, Bergh K. Adsorption and release of antibiotics from morselized cancellous bone. In vitro studies of 8 antibiotics. Acta Orthop Scand. 1999;70(3):298–304.

Witsø E, Persen L, Løseth K, Benum P, Bergh K. Cancellous bone as an antibiotic carrier. Acta Orthop Scand. 2000;71(1):80–84.

Kanellakopoulou K, Sahinides T, Tsaganos T, Galanakis N, Giamarellou H, Giamarellos-Bourboulis EJ. In vitro elution of moxifloxacin from cancellous bone allografts. J Biomed Mater Res Part A. 2010;92A(1):52–55.

Lewis CS, Katz J, Baker MI, Supronowicz PR, Gill E, Cobb RR. Local antibiotic delivery with bovine cancellous chips. J Biomater Appl. 2011;26(4):491–506.

Melicherčík P, Jahoda D, Nyč O, Klapková E, Barták V, Landor I. et al. Bone grafts as vancomycin carriers in local therapy of resistant infections. Folia Microbiol (Praha) 2012;57(5):459–462.

Melichercik P, Klapkova E, Landor I, Judl T, Sibek M, Jahoda D. The effect of Vancomycin degradation products in the topical treatment of osteomyelitis. Bratisl Lek Listy. 2014;115(12):796–9.

Day RE, Megson S, Wood D. Iontophoresis as a means of delivering antibiotics into allograft bone. J Bone Joint Surg Br The British Editorial Society of Bone and Joint Surgery. 2005;87(-B 11):1568–1574.

Edmondson MC, Day R, Wood D. Vancomycin iontophoresis of allograft bone. Bone Joint Res. 2014;3(4):101–107. [PMC free article]

Ketonis C, Barr S, Adams CS, Hickok NJ, Parvizi J. Bacterial colonization of bone allografts: establishment and effects of antibiotics. Clin Orthop Relat Res. 2010;468(8):2113–21. [PMC free article]

Witsø E, Persen L, Benum P, Bergh K. Cortical allograft as a vehicle for antibiotic delivery. Acta Orthop. 2005;76(4):481–486.

Winkler H, Janata O, Berger C, Wein W, Georgopoulos A. In vitro release of vancomycin and tobramycin from impregnated human and bovine bone grafts. J Antimicrob Chemother. 2000;46(3):423–428.

Witsø E, Persen L, Benum P, Bergh K. Release of netilmicin and vancomycin from cancellous bone. Acta Orthop Scand. 2002;73(2):199–205.

Coraça-Huber DC, Ammann CG, Nogler M, Fille M, Frommelt L, Kühn K-D. et al. Lyophilized allogeneic bone tissue as an antibiotic carrier. Cell Tissue Bank. 2016;17(4):629–642. [PMC free article]

Kucera T, Ryskova L, Soukup T, Malakova J, Cermakova E, Mericka P. et al. Elution kinetics of vancomycin and gentamicin from carriers and their effects on mesenchymal stem cell proliferation: an in vitro study. BMC Musculoskelet Disord. 2017;18(1):381. [PMC free article]

Hornyák I, Madácsi E, Kalugyer P, Vácz G, Horváthy DB, Szendrői M. et al. Increased release time of antibiotics from bone allografts through a novel biodegradable coating. Biomed Res Int. 2014;2014:459867. [PMC free article]

Winkler H, Kaudela K, Stoiber A, Menschik F. Bone grafts impregnated with antibiotics as a tool for treating infected implants in orthopedic surgery - one stage revision results. Cell Tissue Bank. 2006;7(4):319–323.

Winkler H, Stoiber A, Kaudela K, Winter F, Menschik F. One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics. J Bone Joint Surg Br. 2008;90(12):1580–4.

Mathijssen NM, Hannink G, Pilot P, Schreurs BW, Bloem RM, Buma P. Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats. BMC Musculoskelet Disord. 2012;13(1):44. [PMC free article]

Shah MR, Patel RR, Solanki R V, Gupta SH. Estimation of drug absorption in antibiotic soaked bone grafts. Indian J Orthop. 2016;50(6):669–676. [PMC free article]

Coraça-Huber DC, Hausdorfer J, Fille M, Steidl M, Nogler M. Effect of two cleaning processes for bone allografts on gentamicin impregnation and in vitro antibiotic release. Cell Tissue Bank. 2013;14(2):221–229.

Ketonis C, Barr S, Adams CS, Shapiro IM, Parvizi J, Hickok NJ. Vancomycin bonded to bone grafts prevents bacterial colonization. Antimicrob Agents Chemother. 2011;55(2):487–94. [PMC free article]

Ketonis C, Barr S, Shapiro IM, Parvizi J, Adams CS, Hickok NJ. Antibacterial activity of bone allografts: Comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin. Bone. 2011;48(3):631–638. [PMC free article]

Zahar A, Kocsis G, Citak M, Puskás G, Domahidy M, Hajdú M. et al. Use of antibiotic-impregnated bone grafts in a rabbit osteomyelitis model. Technol Health Care. 2017;25(5):929–938.

Ozturk AM, Tabak AY, Aktekin CN, Altay M, Erdemli E, Karahuseyinoglu S. et al. Alendronate enhances antibiotic-impregnated bone grafts in the treatment of osteomyelitis. Int Orthop. 2008;32(6):821–827. [PMC free article]

Coraça-Huber DC, Putzer D, Fille M, Hausdorfer J, Nogler M, Kühn K-D. Gentamicin palmitate as a new antibiotic formulation for mixing with bone tissue and local release. Cell Tissue Bank. 2014;15(1):139–144.

Rathbone CR, Cross JD, Brown K V, Murray CK, Wenke JC. Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res. 2011;29(7):1070–1074.

Antoci V, Adams CS, Hickok NJ, Shapiro IM, Parvizi J. Antibiotics for Local Delivery Systems Cause Skeletal Cell Toxicity In vitro. Clin Orthop Relat Res. 2007;462:200–206.

Edin ML, Miclau T, Lester GE, Lindsey RW, Dahners LE. Effect of cefazolin and vancomycin on osteoblasts in vitro. Clin Orthop Relat Res. 1996;(333):245–51.

Miclau T, Edin ML, Lester GE, Lindsey RW, Dahners LE. Bone toxicity of locally applied aminoglycosides. J Orthop Trauma. 1995;9(5):401–6.

Pilge H, Fröbel J, Lensing-Höhn S, Zilkens C, Krauspe R. Cefazolin Irreversibly Inhibits Proliferation and Migration of Human Mesenchymal Stromal Cells. Biomed Res Int. 2016;2016:1–6. [PMC free article]

Salzmann GM, Naal FD, Knoch F von, Tuebel J, Gradinger R, Imhoff AB. et al. Effects of cefuroxime on human osteoblasts in vitro. J Biomed Mater Res Part A. 2007;82A(2):462–468.

Ince A, Schütze N, Karl N, Löhr JF, Eulert J. Gentamicin negatively influenced osteogenic function in vitro. Int Orthop. 2007;31(2):223–228. [PMC free article]

Naal FD, Salzmann GM, Knoch F von, Tuebel J, Diehl P, Gradinger R. et al. The effects of clindamycin on human osteoblasts in vitro. Arch Orthop Trauma Surg. 2008;128(3):317–323.

Barckman J. Bone allograft and implant fixation tested under influence of bio-burden reduction, periosteal augmentation and topical antibiotics. Animal experimental studies. Dan Med J. 2014;61(1):B4720.

Lindsey RW, Probe R, Miclau T, Alexander JW, Perren SM. The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing. Clin Orthop Relat Res. 1993;(291):303–12.

Buttaro M, González Della Valle A, Piñeiro L, Mocetti E, Morandi A, Piccaluga F. Incorporation of vancomycin-supplemented bone allograftsRadiographical, histopathological and immunohistochemical study in pigs. Acta Orthop Scand. 2003;74(5):505–513.

Michalak KA, Khoo PPC, Yates PJ, Day RE, Wood DJ. Iontophoresed segmental allografts in revision arthroplasty for infection. J Bone Joint Surg Br. 2006;88(-B 11):1430–1437.

Buttaro MA, Pusso R, Piccaluga F. Vancomycin-supplemented impacted bone allografts in infected hip arthroplasty. Two-stage revision results. J Bone Joint Surg Br. 2005;87(3):314–9.

Khoo PPC, Michalak KA, Yates PJ, Megson SM, Day RE, Wood DJ. Iontophoresis of antibiotics into segmental allografts. J Bone Joint Surg Br. 2006;88(9):1149–57.

Chen C-E, Ko J-Y, Pan C-C. Results of vancomycin-impregnated cancellous bone grafting for infected tibial nonunion. Arch Orthop Trauma Surg. 2005;125(6):369–375.

Buttaro MA, Morandi A, Rivello HG, Piccaluga F. Histology of vancomycin-supplemented impacted bone allografts in revision total hip arthroplasty. J Bone Joint Surg Br. 2005;87(12):1684–7.

Chan YS, Ueng SW, Wang CJ, Lee SS, Chen CY, Shin CH. Antibiotic-impregnated autogenic cancellous bone grafting is an effective and safe method for the management of small infected tibial defects: a comparison study. J Trauma. 2000;48(2):246–55.

Coraça-Huber DC, Wurm A, Fille M, Hausdorfer J, Nogler M, Kühn K-D. Effect of freezing on the release rate of gentamicin palmitate and gentamicin sulfate from bone tissue. J Orthop Res. 2014;32(6):842–847.

Mathijssen NM, Petit PL, Pilot P, Schreurs BW, Buma P, Bloem RM. Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study. BMC Musculoskelet Disord. 2010;11(1):96. [PMC free article]

Buttaro MA, Gimenez MI, Greco G, Barcan L, Piccaluga F. High active local levels of vancomycin without nephrotoxicity released from impacted bone allografts in 20 revision hip arthroplasties. Acta Orthop. 2005;76(3):336–40.

Buttaro MA, Guala AJ, Comba F, Suarez F, Piccaluga F. Incidence of deep infection in aseptic revision THA using vancomycin-impregnated impacted bone allograft. Hip Int. 2010;20(4):535–41.

Borkhuu B, Borowski A, Shah SA, Littleton AG, Dabney KW, Miller F. Antibiotic-Loaded Allograft Decreases the Rate of Acute Deep Wound Infection After Spinal Fusion in Cerebral Palsy. Spine (Phila Pa 1976) 2008;33(21):2300–2304.

Nart J, Tapia B de, Pujol À, Pascual A, Valles C. Vancomycin and tobramycin impregnated mineralized allograft for the surgical regenerative treatment of peri-implantitis: a 1-year follow-up case series. Clin Oral Investig. 2018;22(6):2199–2207.

Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res. 2014;9(1):18. [PMC free article]

Pierannunzii L, Zagra L. Bone grafts, bone graft extenders, substitutes and enhancers for acetabular reconstruction in revision total hip arthroplasty. EFORT Open Rev. 2016;1(12):431–439. [PMC free article]

Bormann N, Schwabe P, Smith MD, Wildemann B. Analysis of parameters influencing the release of antibiotics mixed with bone grafting material using a reliable mixing procedure. Bone Elsevier. 2014;59:162–172.

Perl TM. The threat of vancomycin resistance. Am J Med. 1999;106(5AS):26–37. discussion 48S-52S.

Barna JC, Williams DH. The structure and mode of action of glycopeptide antibiotics of the vancomycin group. Annu Rev Microbiol. 1984;38(1):339–57.

Winkler H, Haiden P. Allograft Bone as Antibiotic Carrier. J bone Jt Infect Ivyspring International Publisher. 2017;2(1):52–62. [PMC free article]

Winkler H, Haiden P. Allograft Bone as Antibiotic Carrier. J Bone Jt Infect. 2017;2(1):52–62. [PMC free article]

Winkler H. Treatment of chronic orthopaedic infection. EFORT Open Rev The British Editorial Society of Bone and Joint SurgeryLondon. 2017;2(5):110–116. [PMC free article]

Frommelt L. Anwendung von Antibiotika im Knochen. Orthopade. 2018;47(1):24–29.