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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 4, issue 5
J. Bone Joint Infect., 4, 245–253, 2019
https://doi.org/10.7150/jbji.38373
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 4, 245–253, 2019
https://doi.org/10.7150/jbji.38373
© Author(s) 2019. This work is distributed under
the Creative Commons Attribution 4.0 License.

Review 15 Oct 2019

Review | 15 Oct 2019

Current Insights in the Application of Bone Grafts for Local Antibiotic Delivery in Bone Reconstruction Surgery

Arne Peeters1, Guy Putzeys2, and Lieven Thorrez3 Arne Peeters et al.
  • 1Faculty of Medicine, KU Leuven, Leuven, Belgium
  • 2Orthopedic Centre, AZ Groeninge, Kortrijk, Belgium
  • 3Department of Development and Regeneration, KU Leuven, Kortrijk, Belgium

Keywords: bone grafts, impregnation, antibiotic delivery, infection

Abstract. Introduction: Bone implant related infection is still one of the biggest challenges in bone and joint surgery. Antibiotic impregnated bone grafts seem to be promising in both treatment and prevention of these infections. However, great variance in methodology predominates this field of research. This paper gives an overview of the published literature.

Methods: The PRISMA-flowchart was used as protocol for article selection. Medline was searched and articles were selected in accordance with predetermined exclusion criteria.

Results: Forty-eight articles were included in the synthesis. Topics including bone graft type, manipulations of the graft, elution profile, bacterial inhibition, osteotoxicity, incorporation, special impregnation methods, clinical use and storage were investigated.

Therapeutically, high initial levels seem appropriate for biofilm eradication. A single stage procedure in the treatment of bone implant related infection seems feasible. Prophylactically, the literature indicates a reduction of postoperative infections when using antibiotic impregnated bone grafts.

Conclusion: Bone grafts are a suitable carrier for local antibiotic application both therapeutically and prophylactically.

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