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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 3, issue 4
J. Bone Joint Infect., 3, 207–211, 2018
https://doi.org/10.7150/jbji.27811
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 3, 207–211, 2018
https://doi.org/10.7150/jbji.27811
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Original full-length article 04 Oct 2018

Original full-length article | 04 Oct 2018

Daptomycin Plus Fosfomycin as Salvage Therapy in a Difficult-to-Treat Total Femoral Replacement Infection

Gonzalo Luengo1, Jaime Lora-Tamayo2, Diana Paredes2, Irene Muñoz-Gallego3, Antonio Díaz4, and Emilio Delgado1 Gonzalo Luengo et al.
  • 1Department of Orthopaedic surgery and Traumatology, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
  • 2Department of Internal Medicine, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
  • 3Department of Microbiology, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.
  • 4Department of Plastic Surgery, Hospital Universitario 12 de Octubre. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12). Madrid, Spain.

Keywords: prosthetic joint infection, biofilm, Staphylococcus, bone and joint infection

Abstract. The highly active anti-biofilm combination of daptomycin plus fosfomycin was successfully used in a difficult-to-treat infection of a total femoral replacement caused by multi-drug resistant Staphylococcus epidermidis in a 79-year-old woman. There was no need to remove the orthopedic hardware, and the patient is currently pain free and able to walk.

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