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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 3, issue 1
J. Bone Joint Infect., 3, 10–14, 2018
https://doi.org/10.7150/jbji.21567
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 3, 10–14, 2018
https://doi.org/10.7150/jbji.21567
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Original full-length article 13 Jan 2018

Original full-length article | 13 Jan 2018

Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals

Emeli Månsson1,2,4, Berolla Sahdo2, Åsa Nilsdotter-Augustinsson5, Eva Särndahl1,2, and Bo Söderquist1,3 Emeli Månsson et al.
  • 1School of Medical Sciences,
  • 2iRiSC - Inflammatory Response and Infection Susceptibility Centre,
  • 4Region Västmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland Västerås, SE-721 89 Västerås, Sweden;
  • 5Department of Infectious Diseases, and Department of Clinical and Experimental Medicine, Linköping University, SE-60182 Norrköping, Sweden.
  • 3Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden;

Keywords: Staphylococcus epidermidis, prosthetic joint infections, host-pathogen interaction, caspase-1, neutrophils

Abstract. Nosocomial sequence types of Staphylococcus epidermidis dominate in prosthetic joint infections. We examined caspase-1 activation in human neutrophils after incubation with Staphylococcus epidermidis isolated from prosthetic joint infections and normal skin flora. Active caspase-1 was lower after incubation with isolates from prosthetic joint infections than after incubation with commensal isolates. Both host and isolate dependent differences in active caspase-1 were noted. Our results indicate that there might be a host-dependent incapacity to elicit a strong caspase-1 response towards certain strains of S. epidermidis. Further experiments with a larger number of individuals are warranted.

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