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Journal of Bone and Joint Infection An open-access journal of the European Bone and Joint Infection Society and the MusculoSkeletal Infection Society
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Volume 2, issue 2
J. Bone Joint Infect., 2, 84–89, 2017
https://doi.org/10.7150/jbji.17507
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.
J. Bone Joint Infect., 2, 84–89, 2017
https://doi.org/10.7150/jbji.17507
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 4.0 License.

Original full-length article 17 Jan 2017

Original full-length article | 17 Jan 2017

Bone Inflammation, Bone Infection and Dental Implants Failure: Histological and Cytological Aspects Related to Cement Excess

Marco Tatullo1, Massimo Marrelli2, Filiberto Mastrangelo3, and Enrico Gherlone3 Marco Tatullo et al.
  • 1Biomedical Section, Tecnologica Research Institute, Crotone, Italy.
  • 2Maxillofacial Unit, Calabrodental clinic, Crotone, Italy.
  • 3Department of Oral Science, “Vita e Salute” San Raffaele University, Milan, Italy.

Keywords: implant failure, osteoblasts, osseointegration.

Abstract. Background: Dental implant failure can recognize several causes and many of them are quite preventable with the right knowledge of some clinical critical factors. Aim of this paper is to investigate about the histological aspects related to dental implants failure in such cases related to cement excess, how such histological picture can increase the risk of bacterial infections and how the different type of cement can interact with osteoblasts in-vitro.

Methods: We randomly selected 5 patients with a diagnosis of dental implant failure requiring to be surgically removed: in all patients was observed an excess of dental cement around the failed implants. Histological investigations were performed of the perimplant bone. Cell culture of purchased human Osteoblasts was performed in order to evaluate cell proliferation and cell morphology at 3 time points among 3 cement types and a control surface.

Results: Dental cement has been related to a pathognomonic histological picture with a foreign body reaction and many areas with black particles inside macrophage cells. Finally, cell culture on different dental cements resulted in a lower osteoblasts survival rate.

Conclusions: It is appropriate that the dentist puts a small amount of dental cement in the prosthetic crown, so to avoid the clinical alterations related to the excess of cement.

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