Articles | Volume 2, issue 1
J. Bone Joint Infect., 2, 29–37, 2017
J. Bone Joint Infect., 2, 29–37, 2017

Review 01 Jan 2017

Review | 01 Jan 2017

Therapeutic Use of Antibiotic-loaded Bone Cement in the Treatment of Hip and Knee Joint Infections

Konstantinos Anagnostakos Konstantinos Anagnostakos
  • Zentrum für Orthopädie und Unfallchirurgie, Klinikum Saarbrücken, Saarbrücken, Germany.

Keywords: hip spacer, knee spacer, hip infection, knee infection, antibiotic-loaded bone cement.

Abstract. The use of antibiotic-loaded cement spacers is an established method in the management of periprosthetic hip and knee joint infections. Despite inconsistencies among published studies, data shows that infection control rates exceed 90% with two-stage exchange arthroplasty. The present work reviews the current literature about antibiotic-loaded cement spacers and concentrates on the indications for spacer implantation, spacer production details, antibiotic impregnation, pharmacokinetic properties, clinical success, mechanical complications, and systemic safety.